Won’t you come on in? How to favor lymphocyte infiltration in tumors

Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cel...

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Detalles Bibliográficos
Autores principales: Bellone, Matteo, Calcinotto, Arianna, Corti, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489769/
https://www.ncbi.nlm.nih.gov/pubmed/23162781
http://dx.doi.org/10.4161/onci.20213
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author Bellone, Matteo
Calcinotto, Arianna
Corti, Angelo
author_facet Bellone, Matteo
Calcinotto, Arianna
Corti, Angelo
author_sort Bellone, Matteo
collection PubMed
description Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.
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spelling pubmed-34897692012-11-16 Won’t you come on in? How to favor lymphocyte infiltration in tumors Bellone, Matteo Calcinotto, Arianna Corti, Angelo Oncoimmunology Author's View Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489769/ /pubmed/23162781 http://dx.doi.org/10.4161/onci.20213 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Bellone, Matteo
Calcinotto, Arianna
Corti, Angelo
Won’t you come on in? How to favor lymphocyte infiltration in tumors
title Won’t you come on in? How to favor lymphocyte infiltration in tumors
title_full Won’t you come on in? How to favor lymphocyte infiltration in tumors
title_fullStr Won’t you come on in? How to favor lymphocyte infiltration in tumors
title_full_unstemmed Won’t you come on in? How to favor lymphocyte infiltration in tumors
title_short Won’t you come on in? How to favor lymphocyte infiltration in tumors
title_sort won’t you come on in? how to favor lymphocyte infiltration in tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489769/
https://www.ncbi.nlm.nih.gov/pubmed/23162781
http://dx.doi.org/10.4161/onci.20213
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