Turning the tumor microenvironment into a self vaccine site

We aimed to determine if the tumor microenvironment could be turned into a “self”-vaccine site. We show that provoking a local inflammatory response modulates endothelia to permit the infiltration of innate and adaptive effector cells which collaborate to eradicate the inflamed tumor and other tumor...

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Detalles Bibliográficos
Autor principal: Nelson, Delia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489770/
https://www.ncbi.nlm.nih.gov/pubmed/23162782
http://dx.doi.org/10.4161/onci.20238
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author Nelson, Delia J.
author_facet Nelson, Delia J.
author_sort Nelson, Delia J.
collection PubMed
description We aimed to determine if the tumor microenvironment could be turned into a “self”-vaccine site. We show that provoking a local inflammatory response modulates endothelia to permit the infiltration of innate and adaptive effector cells which collaborate to eradicate the inflamed tumor and other tumor deposits, and provide long-term protection.
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spelling pubmed-34897702012-11-16 Turning the tumor microenvironment into a self vaccine site Nelson, Delia J. Oncoimmunology Author's View We aimed to determine if the tumor microenvironment could be turned into a “self”-vaccine site. We show that provoking a local inflammatory response modulates endothelia to permit the infiltration of innate and adaptive effector cells which collaborate to eradicate the inflamed tumor and other tumor deposits, and provide long-term protection. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489770/ /pubmed/23162782 http://dx.doi.org/10.4161/onci.20238 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Nelson, Delia J.
Turning the tumor microenvironment into a self vaccine site
title Turning the tumor microenvironment into a self vaccine site
title_full Turning the tumor microenvironment into a self vaccine site
title_fullStr Turning the tumor microenvironment into a self vaccine site
title_full_unstemmed Turning the tumor microenvironment into a self vaccine site
title_short Turning the tumor microenvironment into a self vaccine site
title_sort turning the tumor microenvironment into a self vaccine site
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489770/
https://www.ncbi.nlm.nih.gov/pubmed/23162782
http://dx.doi.org/10.4161/onci.20238
work_keys_str_mv AT nelsondeliaj turningthetumormicroenvironmentintoaselfvaccinesite

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