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Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections
Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to tre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489779/ https://www.ncbi.nlm.nih.gov/pubmed/22913518 http://dx.doi.org/10.1186/1746-160X-8-23 |
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author | da Silva, Newton Guerreiro Carreira, Aline Semblano Dias Pedreira, Erick Nelo Tuji, Fabrício Mesquita Ortega, Karem López de Jesus Viana Pinheiro, João |
author_facet | da Silva, Newton Guerreiro Carreira, Aline Semblano Dias Pedreira, Erick Nelo Tuji, Fabrício Mesquita Ortega, Karem López de Jesus Viana Pinheiro, João |
author_sort | da Silva, Newton Guerreiro |
collection | PubMed |
description | Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to treat central giant cell lesions. A case of a 36-year-old male with a central giant cell lesion crossing the mandibular midline was treated with intralesional corticosteroids combined with alendronate sodium for the control of systemic bone resorption. The steroid injections and the use of bisphosphonates were stopped after seven months when further needle penetration into the lesion was not possible due to new bone formation. After two years, the bony architecture was near normal, and only minimal radiolucency was present around the root apices of the involved teeth. The patient was followed up for four years, and panoramic radiography showed areas of new bone formation. Thus far, neither recurrence nor side effects of the medication have been detected. |
format | Online Article Text |
id | pubmed-3489779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34897792012-11-06 Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections da Silva, Newton Guerreiro Carreira, Aline Semblano Dias Pedreira, Erick Nelo Tuji, Fabrício Mesquita Ortega, Karem López de Jesus Viana Pinheiro, João Head Face Med Case Report Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to treat central giant cell lesions. A case of a 36-year-old male with a central giant cell lesion crossing the mandibular midline was treated with intralesional corticosteroids combined with alendronate sodium for the control of systemic bone resorption. The steroid injections and the use of bisphosphonates were stopped after seven months when further needle penetration into the lesion was not possible due to new bone formation. After two years, the bony architecture was near normal, and only minimal radiolucency was present around the root apices of the involved teeth. The patient was followed up for four years, and panoramic radiography showed areas of new bone formation. Thus far, neither recurrence nor side effects of the medication have been detected. BioMed Central 2012-08-22 /pmc/articles/PMC3489779/ /pubmed/22913518 http://dx.doi.org/10.1186/1746-160X-8-23 Text en Copyright ©2012 da Silva et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report da Silva, Newton Guerreiro Carreira, Aline Semblano Dias Pedreira, Erick Nelo Tuji, Fabrício Mesquita Ortega, Karem López de Jesus Viana Pinheiro, João Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
title | Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
title_full | Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
title_fullStr | Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
title_full_unstemmed | Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
title_short | Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
title_sort | treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489779/ https://www.ncbi.nlm.nih.gov/pubmed/22913518 http://dx.doi.org/10.1186/1746-160X-8-23 |
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