Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Galectins are pleiotropic carbohydrate-binding lectins involved in inflammation, growth/differentiation, and tissue remodeling. The functional role of galectins in amyotrophic lateral sclerosis (ALS) is unknown. Expression studies revealed increases in galectin-1 mRNA and protein in spinal cords fro...

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Detalles Bibliográficos
Autores principales: Lerman, Bruce J, Hoffman, Eric P, Sutherland, Margaret L, Bouri, Khaled, Hsu, Daniel K, Liu, Fu-Tong, Rothstein, Jeffrey D, Knoblach, Susan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489809/
https://www.ncbi.nlm.nih.gov/pubmed/23139902
http://dx.doi.org/10.1002/brb3.75

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