Multigenerational Epigenetic Adaptation of the Hepatic Wound-Healing Response

We asked if ancestral liver damage leads to heritable reprogramming of hepatic wound-healing. We discovered that male rats with a history of liver damage transmit epigenetic suppressive adaptation of the fibrogenic component of wound-healing through male F(1) and F(2) generations. Underlying this ad...

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Detalles Bibliográficos
Autores principales: Zeybel, Müjdat, Hardy, Timothy, Wong, Yi K., Mathers, John C., Fox, Christopher R., Gackowska, Agata, Oakley, Fiona, Burt, Alastair D., Wilson, Caroline L., Anstee, Quentin M., Barter, Matt J., Masson, Steven, Elsharkawy, Ahmed M., Mann, Derek A., Mann, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489975/
https://www.ncbi.nlm.nih.gov/pubmed/22941276
http://dx.doi.org/10.1038/nm.2893

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