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Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin
The burden of increasing morbidity and mortality due to prostate cancer imposes a need for new, effective measures of prevention in daily life. The influence of lifestyle on carcinogenesis in Asian men who migrate to Western cultures supports a causal role for dietary, environmental, and genetic fac...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Urological Association
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490085/ https://www.ncbi.nlm.nih.gov/pubmed/23136625 http://dx.doi.org/10.4111/kju.2012.53.10.665 |
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author | Horie, Shigeo |
author_facet | Horie, Shigeo |
author_sort | Horie, Shigeo |
collection | PubMed |
description | The burden of increasing morbidity and mortality due to prostate cancer imposes a need for new, effective measures of prevention in daily life. The influence of lifestyle on carcinogenesis in Asian men who migrate to Western cultures supports a causal role for dietary, environmental, and genetic factors in the epidemiology of prostate cancer. Chemoprevention, a prophylactic approach that uses nontoxic natural or synthetic compounds to reverse, inhibit, or prevent cancer by targeting specific steps in the carcinogenic pathway, is gaining traction among health care practitioners. Soy isoflavones and curcumin, staples of the Asian diet, have shown promise as functional factors for the chemoprevention of prostate cancer because of their ability to modulate multiple intracellular signaling pathways, including cellular proliferation, apoptosis, inflammation, and androgen receptor signaling. Recent evidence has revealed the DNA damage response (DDR) to be one of the earliest events in the multistep progression of human epithelial carcinomas to invasive malignancy. Soy isoflavones and curcumin activate the DDR, providing an opportunity and rationale for the clinical application of these nutraceuticals in the chemoprevention of prostate cancer. |
format | Online Article Text |
id | pubmed-3490085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-34900852012-11-07 Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin Horie, Shigeo Korean J Urol Review Article The burden of increasing morbidity and mortality due to prostate cancer imposes a need for new, effective measures of prevention in daily life. The influence of lifestyle on carcinogenesis in Asian men who migrate to Western cultures supports a causal role for dietary, environmental, and genetic factors in the epidemiology of prostate cancer. Chemoprevention, a prophylactic approach that uses nontoxic natural or synthetic compounds to reverse, inhibit, or prevent cancer by targeting specific steps in the carcinogenic pathway, is gaining traction among health care practitioners. Soy isoflavones and curcumin, staples of the Asian diet, have shown promise as functional factors for the chemoprevention of prostate cancer because of their ability to modulate multiple intracellular signaling pathways, including cellular proliferation, apoptosis, inflammation, and androgen receptor signaling. Recent evidence has revealed the DNA damage response (DDR) to be one of the earliest events in the multistep progression of human epithelial carcinomas to invasive malignancy. Soy isoflavones and curcumin activate the DDR, providing an opportunity and rationale for the clinical application of these nutraceuticals in the chemoprevention of prostate cancer. The Korean Urological Association 2012-10 2012-10-19 /pmc/articles/PMC3490085/ /pubmed/23136625 http://dx.doi.org/10.4111/kju.2012.53.10.665 Text en © The Korean Urological Association, 2012 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Horie, Shigeo Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin |
title | Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin |
title_full | Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin |
title_fullStr | Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin |
title_full_unstemmed | Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin |
title_short | Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin |
title_sort | chemoprevention of prostate cancer: soy isoflavones and curcumin |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490085/ https://www.ncbi.nlm.nih.gov/pubmed/23136625 http://dx.doi.org/10.4111/kju.2012.53.10.665 |
work_keys_str_mv | AT horieshigeo chemopreventionofprostatecancersoyisoflavonesandcurcumin |