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THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM
The relationship between form and function can have profound effects on evolutionary dynamics and such effects may differ for simple versus complex systems. In particular, functions produced by multiple structural configurations (many-to-one mapping, MTOM) may dampen constituent trade-offs and promo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Inc
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490443/ https://www.ncbi.nlm.nih.gov/pubmed/23106702 http://dx.doi.org/10.1111/j.1558-5646.2012.01688.x |
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author | Parnell, Nicholas F Hulsey, C Darrin Streelman, J Todd |
author_facet | Parnell, Nicholas F Hulsey, C Darrin Streelman, J Todd |
author_sort | Parnell, Nicholas F |
collection | PubMed |
description | The relationship between form and function can have profound effects on evolutionary dynamics and such effects may differ for simple versus complex systems. In particular, functions produced by multiple structural configurations (many-to-one mapping, MTOM) may dampen constituent trade-offs and promote diversification. Unfortunately, we lack information about the genetic architecture of MTOM functional systems. The skulls of teleost fishes contain both simple (lower jaw levers) as well as more complex (jaws modeled as 4-bar linkages) functional systems within the same craniofacial unit. We examined the mapping of form to function and the genetic basis of these systems by identifying quantitative trait loci (QTL) in hybrids of two Lake Malawi cichlid species. Hybrid individuals exhibited novelty (transgressive segregation) in morphological components and function of the simple and complex jaw systems. Functional novelty was proportional to the prevalence of extreme morphologies in the simple levers; by contrast, recombination of parental morphologies produced transgression in the MTOM 4-bar linkage. We found multiple loci of moderate effect and epistasis controlling jaw phenotypes in both the simple and complex systems, with less phenotypic variance explained by QTL for the 4-bar. Genetic linkage between components of the simple and complex systems partly explains phenotypic correlations and may constrain functional evolution. |
format | Online Article Text |
id | pubmed-3490443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-34904432013-01-09 THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM Parnell, Nicholas F Hulsey, C Darrin Streelman, J Todd Evolution Original Articles The relationship between form and function can have profound effects on evolutionary dynamics and such effects may differ for simple versus complex systems. In particular, functions produced by multiple structural configurations (many-to-one mapping, MTOM) may dampen constituent trade-offs and promote diversification. Unfortunately, we lack information about the genetic architecture of MTOM functional systems. The skulls of teleost fishes contain both simple (lower jaw levers) as well as more complex (jaws modeled as 4-bar linkages) functional systems within the same craniofacial unit. We examined the mapping of form to function and the genetic basis of these systems by identifying quantitative trait loci (QTL) in hybrids of two Lake Malawi cichlid species. Hybrid individuals exhibited novelty (transgressive segregation) in morphological components and function of the simple and complex jaw systems. Functional novelty was proportional to the prevalence of extreme morphologies in the simple levers; by contrast, recombination of parental morphologies produced transgression in the MTOM 4-bar linkage. We found multiple loci of moderate effect and epistasis controlling jaw phenotypes in both the simple and complex systems, with less phenotypic variance explained by QTL for the 4-bar. Genetic linkage between components of the simple and complex systems partly explains phenotypic correlations and may constrain functional evolution. Blackwell Publishing Inc 2012-11 2012-05-28 /pmc/articles/PMC3490443/ /pubmed/23106702 http://dx.doi.org/10.1111/j.1558-5646.2012.01688.x Text en © 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Original Articles Parnell, Nicholas F Hulsey, C Darrin Streelman, J Todd THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM |
title | THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM |
title_full | THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM |
title_fullStr | THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM |
title_full_unstemmed | THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM |
title_short | THE GENETIC BASIS OF A COMPLEX FUNCTIONAL SYSTEM |
title_sort | genetic basis of a complex functional system |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490443/ https://www.ncbi.nlm.nih.gov/pubmed/23106702 http://dx.doi.org/10.1111/j.1558-5646.2012.01688.x |
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