Seven newly identified loci for autoimmune thyroid disease

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide po...

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Detalles Bibliográficos
Autores principales: Cooper, Jason D., Simmonds, Matthew J., Walker, Neil M., Burren, Oliver, Brand, Oliver J., Guo, Hui, Wallace, Chris, Stevens, Helen, Coleman, Gillian, Franklyn, Jayne A., Todd, John A., Gough, Stephen C.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518/
https://www.ncbi.nlm.nih.gov/pubmed/22922229
http://dx.doi.org/10.1093/hmg/dds357
Descripción
Sumario:Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(−6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

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