Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen

Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemi...

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Detalles Bibliográficos
Autores principales: Lhotáková, Yveta, Plíštil, Lukáš, Morávková, Alena, Kubát, Pavel, Lang, Kamil, Forstová, Jitka, Mosinger, Jiří
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490908/
https://www.ncbi.nlm.nih.gov/pubmed/23139839
http://dx.doi.org/10.1371/journal.pone.0049226
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author Lhotáková, Yveta
Plíštil, Lukáš
Morávková, Alena
Kubát, Pavel
Lang, Kamil
Forstová, Jitka
Mosinger, Jiří
author_facet Lhotáková, Yveta
Plíštil, Lukáš
Morávková, Alena
Kubát, Pavel
Lang, Kamil
Forstová, Jitka
Mosinger, Jiří
author_sort Lhotáková, Yveta
collection PubMed
description Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemical and biological substrates/targets. Strong photo-virucidal effects toward non-enveloped polyomaviruses and enveloped baculoviruses were observed on the surface of these textiles. The photo-virucidal effect was confirmed by a decrease in virus infectivity. In contrast, no virucidal effect was detected in the absence of light and/or the encapsulated photosensitizer.
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spelling pubmed-34909082012-11-08 Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen Lhotáková, Yveta Plíštil, Lukáš Morávková, Alena Kubát, Pavel Lang, Kamil Forstová, Jitka Mosinger, Jiří PLoS One Research Article Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemical and biological substrates/targets. Strong photo-virucidal effects toward non-enveloped polyomaviruses and enveloped baculoviruses were observed on the surface of these textiles. The photo-virucidal effect was confirmed by a decrease in virus infectivity. In contrast, no virucidal effect was detected in the absence of light and/or the encapsulated photosensitizer. Public Library of Science 2012-11-06 /pmc/articles/PMC3490908/ /pubmed/23139839 http://dx.doi.org/10.1371/journal.pone.0049226 Text en © 2012 Lhotáková et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lhotáková, Yveta
Plíštil, Lukáš
Morávková, Alena
Kubát, Pavel
Lang, Kamil
Forstová, Jitka
Mosinger, Jiří
Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen
title Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen
title_full Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen
title_fullStr Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen
title_full_unstemmed Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen
title_short Virucidal Nanofiber Textiles Based on Photosensitized Production of Singlet Oxygen
title_sort virucidal nanofiber textiles based on photosensitized production of singlet oxygen
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490908/
https://www.ncbi.nlm.nih.gov/pubmed/23139839
http://dx.doi.org/10.1371/journal.pone.0049226
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