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Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children
Hand-foot-and-mouth disease (HFMD) and herpangina are commonly prevalent illness in young children. They are similarly characterized by lesions on the skin and oral mucosa. Both diseases are associated with various enterovirus serotypes. In this study, enteroviruses from patients with these diseases...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490919/ https://www.ncbi.nlm.nih.gov/pubmed/22985487 http://dx.doi.org/10.1186/1743-422X-9-205 |
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author | Park, KwiSung Lee, BaeckHee Baek, KyoungAh Cheon, DooSung Yeo, SangGu Park, JoonSoo Soh, JaeWan Cheon, HaeKyung Yoon, KyungAh Choi, YoungJin |
author_facet | Park, KwiSung Lee, BaeckHee Baek, KyoungAh Cheon, DooSung Yeo, SangGu Park, JoonSoo Soh, JaeWan Cheon, HaeKyung Yoon, KyungAh Choi, YoungJin |
author_sort | Park, KwiSung |
collection | PubMed |
description | Hand-foot-and-mouth disease (HFMD) and herpangina are commonly prevalent illness in young children. They are similarly characterized by lesions on the skin and oral mucosa. Both diseases are associated with various enterovirus serotypes. In this study, enteroviruses from patients with these diseases in Korea in 2009 were isolated and analyzed. Demographic data for patients with HFMD and herpangina were compared and all enterovirus isolates were amplified in the VP1 region by reverse transcription-polymerase chain reaction and sequenced. Among the enterovirus isolates, prevalent agents were coxsackievirus A16 in HFMD and coxsackievirus A5 in herpangina. More prevalent months for HFMD were June (69.2%) and May (11.5%), and June (40.0%) and July (24.0%) for herpangina. Age prevalence of HFMD patients with enterovirus infection was 1 year (23.1%), 4 years (19.2%), and over 5 years (19.2%). However, the dominant age group of herpangina patients with enterovirus infection was 1 year (48.0%) followed by 2 years (28.0%). Comparison of pairwise VP1 nucleotide sequence alignment of all isolates within the same serotypes revealed high intra-type variation of CVA2 isolates (84.6–99.3% nucleotide identity). HFMD and herpangina showed differences in demographic data and serotypes of isolated enteroviruses, but there was no notable difference in amino acid sequences by clinical syndromes in multiple comparison of the partial VP1 gene sequence. |
format | Online Article Text |
id | pubmed-3490919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34909192012-11-07 Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children Park, KwiSung Lee, BaeckHee Baek, KyoungAh Cheon, DooSung Yeo, SangGu Park, JoonSoo Soh, JaeWan Cheon, HaeKyung Yoon, KyungAh Choi, YoungJin Virol J Research Hand-foot-and-mouth disease (HFMD) and herpangina are commonly prevalent illness in young children. They are similarly characterized by lesions on the skin and oral mucosa. Both diseases are associated with various enterovirus serotypes. In this study, enteroviruses from patients with these diseases in Korea in 2009 were isolated and analyzed. Demographic data for patients with HFMD and herpangina were compared and all enterovirus isolates were amplified in the VP1 region by reverse transcription-polymerase chain reaction and sequenced. Among the enterovirus isolates, prevalent agents were coxsackievirus A16 in HFMD and coxsackievirus A5 in herpangina. More prevalent months for HFMD were June (69.2%) and May (11.5%), and June (40.0%) and July (24.0%) for herpangina. Age prevalence of HFMD patients with enterovirus infection was 1 year (23.1%), 4 years (19.2%), and over 5 years (19.2%). However, the dominant age group of herpangina patients with enterovirus infection was 1 year (48.0%) followed by 2 years (28.0%). Comparison of pairwise VP1 nucleotide sequence alignment of all isolates within the same serotypes revealed high intra-type variation of CVA2 isolates (84.6–99.3% nucleotide identity). HFMD and herpangina showed differences in demographic data and serotypes of isolated enteroviruses, but there was no notable difference in amino acid sequences by clinical syndromes in multiple comparison of the partial VP1 gene sequence. BioMed Central 2012-09-17 /pmc/articles/PMC3490919/ /pubmed/22985487 http://dx.doi.org/10.1186/1743-422X-9-205 Text en Copyright ©2012 Park et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Park, KwiSung Lee, BaeckHee Baek, KyoungAh Cheon, DooSung Yeo, SangGu Park, JoonSoo Soh, JaeWan Cheon, HaeKyung Yoon, KyungAh Choi, YoungJin Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children |
title | Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children |
title_full | Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children |
title_fullStr | Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children |
title_full_unstemmed | Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children |
title_short | Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children |
title_sort | enteroviruses isolated from herpangina and hand-foot-and-mouth disease in korean children |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490919/ https://www.ncbi.nlm.nih.gov/pubmed/22985487 http://dx.doi.org/10.1186/1743-422X-9-205 |
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