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PAK in Alzheimer disease, Huntington disease and X-linked mental retardation

Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines. Neurodegenerative diseases such as Alzheimer disease (AD), where both PAK1 and PAK3 are dysregulated, may share f...

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Detalles Bibliográficos
Autores principales:	Ma, Qiu-Lan, Yang, Fusheng, Frautschy, Sally A., Cole, Greg M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490962/ https://www.ncbi.nlm.nih.gov/pubmed/23162743 http://dx.doi.org/10.4161/cl.21602

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