Mouse models of PAK function

p21-activated kinases are a family of highly conserved protein serine/threonine kinases that are increasingly recognized as playing essential roles in a variety of key signaling processes. Genetic analyses in mice, using constitutive or regulated gene disruption, have provided important new insights...

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Detalles Bibliográficos
Autores principales: Kelly, Mollie L., Chernoff, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490966/
https://www.ncbi.nlm.nih.gov/pubmed/23162740
http://dx.doi.org/10.4161/cl.21381
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author Kelly, Mollie L.
Chernoff, Jonathan
author_facet Kelly, Mollie L.
Chernoff, Jonathan
author_sort Kelly, Mollie L.
collection PubMed
description p21-activated kinases are a family of highly conserved protein serine/threonine kinases that are increasingly recognized as playing essential roles in a variety of key signaling processes. Genetic analyses in mice, using constitutive or regulated gene disruption, have provided important new insights into PAK function. In this paper, we review the genetic analysis of all six PAK genes in mice. These data address the singular and redundant functions of the various PAK genes and suggest therapeutic possibilities for small molecule PAK inhibitors or activators.
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spelling pubmed-34909662012-11-16 Mouse models of PAK function Kelly, Mollie L. Chernoff, Jonathan Cell Logist Review p21-activated kinases are a family of highly conserved protein serine/threonine kinases that are increasingly recognized as playing essential roles in a variety of key signaling processes. Genetic analyses in mice, using constitutive or regulated gene disruption, have provided important new insights into PAK function. In this paper, we review the genetic analysis of all six PAK genes in mice. These data address the singular and redundant functions of the various PAK genes and suggest therapeutic possibilities for small molecule PAK inhibitors or activators. Landes Bioscience 2012-04-01 /pmc/articles/PMC3490966/ /pubmed/23162740 http://dx.doi.org/10.4161/cl.21381 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Kelly, Mollie L.
Chernoff, Jonathan
Mouse models of PAK function
title Mouse models of PAK function
title_full Mouse models of PAK function
title_fullStr Mouse models of PAK function
title_full_unstemmed Mouse models of PAK function
title_short Mouse models of PAK function
title_sort mouse models of pak function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490966/
https://www.ncbi.nlm.nih.gov/pubmed/23162740
http://dx.doi.org/10.4161/cl.21381
work_keys_str_mv AT kellymolliel mousemodelsofpakfunction
AT chernoffjonathan mousemodelsofpakfunction

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