Presentation of two patients with malignant granulosa cell tumors, with a review of the literature

Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhib...

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Autores principales: Tamura, Ryousuke, Yokoyama, Yoshihito, Yanagita, Takeshi, Matsumura, Yukiko, Abe, Kazuhiro, Taniguchi, Ryousuke, Mizunuma, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490972/
https://www.ncbi.nlm.nih.gov/pubmed/22963202
http://dx.doi.org/10.1186/1477-7819-10-185
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author Tamura, Ryousuke
Yokoyama, Yoshihito
Yanagita, Takeshi
Matsumura, Yukiko
Abe, Kazuhiro
Taniguchi, Ryousuke
Mizunuma, Hideki
author_facet Tamura, Ryousuke
Yokoyama, Yoshihito
Yanagita, Takeshi
Matsumura, Yukiko
Abe, Kazuhiro
Taniguchi, Ryousuke
Mizunuma, Hideki
author_sort Tamura, Ryousuke
collection PubMed
description Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.
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spelling pubmed-34909722012-11-07 Presentation of two patients with malignant granulosa cell tumors, with a review of the literature Tamura, Ryousuke Yokoyama, Yoshihito Yanagita, Takeshi Matsumura, Yukiko Abe, Kazuhiro Taniguchi, Ryousuke Mizunuma, Hideki World J Surg Oncol Case Report Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients. BioMed Central 2012-09-11 /pmc/articles/PMC3490972/ /pubmed/22963202 http://dx.doi.org/10.1186/1477-7819-10-185 Text en Copyright ©2012 Tamura et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tamura, Ryousuke
Yokoyama, Yoshihito
Yanagita, Takeshi
Matsumura, Yukiko
Abe, Kazuhiro
Taniguchi, Ryousuke
Mizunuma, Hideki
Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
title Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
title_full Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
title_fullStr Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
title_full_unstemmed Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
title_short Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
title_sort presentation of two patients with malignant granulosa cell tumors, with a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490972/
https://www.ncbi.nlm.nih.gov/pubmed/22963202
http://dx.doi.org/10.1186/1477-7819-10-185
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