Cargando…

N-Chlorotaurine, a Long-Lived Oxidant Produced by Human Leukocytes, Inactivates Shiga Toxin of Enterohemorrhagic Escherichia coli

N-chlorotaurine (NCT), the main representative of long-lived oxidants produced by granulocytes and monocytes, is known to exert broad-spectrum microbicidal activity. Here we show that NCT directly inactivates Shiga toxin 2 (Stx2), used as a model toxin secreted by enterohemorrhagic Escherichia coli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eitzinger, Christian, Ehrlenbach, Silvia, Lindner, Herbert, Kremser, Leopold, Gottardi, Waldemar, Debabov, Dmitri, Anderson, Mark, Nagl, Markus, Orth, Dorothea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491008/ https://www.ncbi.nlm.nih.gov/pubmed/23139739 http://dx.doi.org/10.1371/journal.pone.0047105

Ejemplares similares

In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
por: Fürnkranz, Ursula, et al.
Publicado: (2011)

N‐chlorotaurine, a potent weapon against multiresistant bacteria
por: Anich, C., et al.
Publicado: (2021)

Tolerability of inhaled N-chlorotaurine in the pig model
por: Geiger, Ralf, et al.
Publicado: (2009)

Successful treatment of a unique chronic multi-bacterial scalp infection with N-chlorotaurine, N-bromotaurine and bromamine T
por: Kyriakopoulos, Anthony M., et al.
Publicado: (2020)

Oxidative Stress in Shiga Toxin Production by Enterohemorrhagic Escherichia coli
por: Licznerska, Katarzyna, et al.
Publicado: (2016)

Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide
por: Mustedanagic, Jasmin, et al.
Publicado: (2017)

Shiga toxin in enterohemorrhagic E.coli: regulation and novel anti-virulence strategies
por: Pacheco, Alline R., et al.
Publicado: (2012)

Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli
por: Warr, Alyson R., et al.
Publicado: (2021)

N-Chlorotaurine, a Promising Future Candidate for Topical Therapy of Fungal Infections
por: Nagl, Markus, et al.
Publicado: (2017)

Activity of N-Chlorotaurine against Long-Term Biofilms of Bacteria and Yeasts
por: Grimus, Victoria, et al.
Publicado: (2021)

N-chlorotaurine is highly active against respiratory viruses including SARS-CoV-2 (COVID-19) in vitro
por: Lackner, Michaela, et al.
Publicado: (2022)

Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli
por: Berger, Michael, et al.
Publicado: (2019)

Infection due to Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) presenting as ischemic colitis
por: Tanquilut, Camille D., et al.
Publicado: (2019)

The structure of the Shiga toxin 2a A‐subunit dictates the interactions of the toxin with blood components
por: Brigotti, Maurizio, et al.
Publicado: (2019)

Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli
por: Xu, Xuefang, et al.
Publicado: (2012)

Therapeutic Strategies to Protect the Central Nervous System against Shiga Toxin from Enterohemorrhagic Escherichia coli
por: Goldstein, Jorge, et al.
Publicado: (2021)

Efficacy of Inhaled N-Chlorotaurine in a Mouse Model of Lichtheimia corymbifera and Aspergillus fumigatus Pneumonia
por: Speth, Cornelia, et al.
Publicado: (2022)

Sub-Lethal Dose of Shiga Toxin 2 from Enterohemorrhagic Escherichia coli Affects Balance and Cerebellar Cytoarchitecture
por: D’Alessio, Luciana, et al.
Publicado: (2016)

Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics against Candida spp. Isolated from Vulvovaginal Candidiasis
por: Hacioglu, Mayram, et al.
Publicado: (2022)

The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage
por: Ogura, Yoshitoshi, et al.
Publicado: (2015)

Degradation and inactivation of Shiga toxins by nitrogen gas plasma
por: Sakudo, Akikazu, et al.
Publicado: (2017)

Serine Protease EspP from Enterohemorrhagic Escherichia Coli Is Sufficient to Induce Shiga Toxin Macropinocytosis in Intestinal Epithelium
por: In, Julie, et al.
Publicado: (2013)

Nitric oxide‐enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O157
por: Ichimura, Kimitoshi, et al.
Publicado: (2017)

Environmental Cues Modulate Microglial Cell Behavior Upon Shiga Toxin 2 From Enterohemorrhagic Escherichia coli Exposure
por: Berdasco, Clara, et al.
Publicado: (2020)

Enterohemorrhagic Escherichia coli and a Fresh View on Shiga Toxin-Binding Glycosphingolipids of Primary Human Kidney and Colon Epithelial Cells and Their Toxin Susceptibility
por: Detzner, Johanna, et al.
Publicado: (2022)

Quantitative Detection of Shiga Toxins Directly from Stool Specimens of Patients Associated with an Outbreak of Enterohemorrhagic Escherichia coli in Japan—Quantitative Shiga toxin detection from stool during EHEC outbreak
por: Yamasaki, Eiki, et al.
Publicado: (2015)

Tolerability of inhaled N-chlorotaurine in humans: a double-blind randomized phase I clinical study
por: Arnitz, Roland, et al.
Publicado: (2018)

Cationic Antimicrobial Peptides Inactivate Shiga Toxin-Encoding Bacteriophages
por: Del Cogliano, Manuel E., et al.
Publicado: (2017)

Tolerability of inhaled N-chlorotaurine in an acute pig streptococcal lower airway inflammation model
por: Schwienbacher, Martin, et al.
Publicado: (2011)

Vitamin B(12) Uptake by the Gut Commensal Bacteria Bacteroides thetaiotaomicron Limits the Production of Shiga Toxin by Enterohemorrhagic Escherichia coli
por: Cordonnier, Charlotte, et al.
Publicado: (2016)

Inhibition of terminal complement activation in severe Shiga toxin-associated HUS – perfect example for a fast track from bench to bedside
por: Orth-Höller, Dorothea, et al.
Publicado: (2011)

Method for the Detection of the Cleaved Form of Shiga Toxin 2a Added to Normal Human Serum
por: Rocchetti, Lucrezia, et al.
Publicado: (2021)

Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in Shiga toxin independent manner
por: Roxas, Jennifer Lising, et al.
Publicado: (2010)

EPS3.05 N-chlorotaurine is a very promising antiseptic treatment option for multiresistant bacteria, fungi and for viruses including SARS-CoV-2
por: Schwarz, C., et al.
Publicado: (2021)

Development of a Multiplex PCR Assay for Detection of Shiga Toxin-Producing Escherichia coli, Enterohemorrhagic E. coli, and Enteropathogenic E. coli Strains
por: Botkin, Douglas J., et al.
Publicado: (2012)

The Prophage and Us—Shiga Toxin Phages Revisited
por: Schmidt, Herbert, et al.
Publicado: (2023)

Lipid Reorganization Induced by Shiga Toxin Clustering on Planar Membranes
por: Windschiegl, Barbara, et al.
Publicado: (2009)

Therapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak
por: Corogeanu, Diana, et al.
Publicado: (2012)

A Macroporous Magnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III Secretory Proteins in Enterohemorrhagic Escherichia coli, Which Attenuates Virulence
por: Hirakawa, Hidetada, et al.
Publicado: (2022)

Toxins of Locus of Enterocyte Effacement-Negative Shiga Toxin-Producing Escherichia coli
por: Krause, Maike, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d583hpgugofpp6ku7ac9j8smji