Cargando…

A Heat-Shock Protein Axis Regulates VEGFR2 Proteolysis, Blood Vessel Development and Repair

Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis. However, the mechanism underlying VEGFR2 turnover and degradation in this response is unclear. Here, we tested a role for heat-shock prot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bruns, Alexander F., Yuldasheva, Nadira, Latham, Antony M., Bao, Leyuan, Pellet-Many, Caroline, Frankel, Paul, Stephen, Sam L., Howell, Gareth J., Wheatcroft, Stephen B., Kearney, Mark T., Zachary, Ian C., Ponnambalam, Sreenivasan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491040/ https://www.ncbi.nlm.nih.gov/pubmed/23139789 http://dx.doi.org/10.1371/journal.pone.0048539

Ejemplares similares

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
por: Fearnley, Gareth W., et al.
Publicado: (2016)

Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation
por: Jopling, Helen M., et al.
Publicado: (2014)

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8
por: Smith, Gina A., et al.
Publicado: (2015)

VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration
por: Fearnley, Gareth W., et al.
Publicado: (2015)

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
por: Smith, Gina A., et al.
Publicado: (2017)

In Silico Design and Biological Evaluation of a Dual Specificity Kinase Inhibitor Targeting Cell Cycle Progression and Angiogenesis
por: Latham, Antony M., et al.
Publicado: (2014)

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking
por: Critchley, William R., et al.
Publicado: (2018)

VEGF-A isoforms differentially regulate ATF-2–dependent VCAM-1 gene expression and endothelial–leukocyte interactions
por: Fearnley, Gareth W., et al.
Publicado: (2014)

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function
por: Fearnley, Gareth W., et al.
Publicado: (2019)

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
por: Smith, Gina A., et al.
Publicado: (2015)

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
por: Herzog, Birger, et al.
Publicado: (2011)

The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function
por: Critchley, William R., et al.
Publicado: (2023)

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice
por: Rode, Baptiste, et al.
Publicado: (2019)

Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling
por: Warmke, Nele, et al.
Publicado: (2021)

Scavenger Receptor Structure and Function in Health and Disease
por: Abdul Zani, Izma, et al.
Publicado: (2015)

Extracellular and Luminal pH Regulation by Vacuolar H(+)-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes
por: Smith, Gina A., et al.
Publicado: (2016)

Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130(Cas)
por: Pellet-Many, Caroline, et al.
Publicado: (2011)

Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease
por: Stephen, Sam L., et al.
Publicado: (2010)

Cell Biology of Membrane Trafficking in Human Disease
por: Howell, Gareth J., et al.
Publicado: (2006)

Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart
por: Lowe, Vanessa, et al.
Publicado: (2019)

Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration
por: Kahn, Matthew B., et al.
Publicado: (2011)

Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms
por: Bridge, Katherine, et al.
Publicado: (2017)

Shunting in chronic hydrocephalus induces VEGFR-2 and blood vessel density changes in the caudate nucleus
por: Luciano, Mark, et al.
Publicado: (2010)

VEGFR3 is required for button junction formation in lymphatic vessels
por: Jannaway, Melanie, et al.
Publicado: (2023)

The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration
por: Lowe, Vanessa, et al.
Publicado: (2021)

IGFBP-1 in Cardiometabolic Pathophysiology—Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice
por: Haywood, Natalie J, et al.
Publicado: (2019)

SUN-084 Aged Insulin Resistant Macrophages Reveal Dysregulated Cholesterol Biosynthesis, Pro-Inflammatory Gene Expression, and Reduced Foam Cell Formation
por: Chabrier, Gwladys, et al.
Publicado: (2019)

Preservation of vascular endothelial repair in mice with diet‐induced obesity
por: Rashid, S. T., et al.
Publicado: (2018)

Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2–, AP-1–, and Rab22-dependent steps
por: Holloway, Zoe G., et al.
Publicado: (2013)

Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
por: Chen, Li, et al.
Publicado: (2010)

Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation
por: Mahmoud, Marwa, et al.
Publicado: (2019)

Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice
por: Sengupta, Anshuman, et al.
Publicado: (2018)

Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction
por: Sukumar, Piruthivi, et al.
Publicado: (2013)

Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis
por: Walker, Andrew M N, et al.
Publicado: (2021)

Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity
por: Imrie, Helen, et al.
Publicado: (2022)

Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
por: Pillay, Vinochani, et al.
Publicado: (2023)

Emerging Roles for Neuropilin-2 in Cardiovascular Disease
por: Harman, Jennifer L., et al.
Publicado: (2020)

Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury
por: Pellet-Many, Caroline, et al.
Publicado: (2015)

Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1)
por: Chappell, John C., et al.
Publicado: (2019)

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice
por: Imrie, Helen, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jsupl1nmrc4sakuenargj7524f