Cargando…

In vivo Genome Editing Using High Efficiency TALENs

The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and human disease using a rich array of in vivo genetic and molecular tools. However, the inability to readily modify the genome in a targeted fashion has been a bottleneck in the field. Here we show that improv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bedell, Victoria M., Wang, Ying, Campbell, Jarryd M., Poshusta, Tanya L., Starker, Colby G., Krug, Randall G., Tan, Wenfang, Penheiter, Sumedha G., Ma, Alvin C., Leung, Anskar Y.H., Fahrenkrug, Scott C., Carlson, Daniel F., Voytas, Daniel F., Clark, Karl J., Essner, Jeffrey J., Ekker, Stephen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491146/ https://www.ncbi.nlm.nih.gov/pubmed/23000899 http://dx.doi.org/10.1038/nature11537

Ejemplares similares

Targeting DNA With Fingers and TALENs
por: Carlson, Daniel F, et al.
Publicado: (2012)

Targeting G with TAL Effectors: A Comparison of Activities of TALENs Constructed with NN and NK Repeat Variable Di-Residues
por: Christian, Michelle L., et al.
Publicado: (2012)

Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome
por: Dahlem, Timothy J., et al.
Publicado: (2012)

Efficient TALEN-mediated gene targeting of chicken primordial germ cells
por: Taylor, Lorna, et al.
Publicado: (2017)

CRISPR/Cas9 and TALENs generate heritable mutations for genes involved in small RNA processing of Glycine max and Medicago truncatula
por: Curtin, Shaun J., et al.
Publicado: (2017)

TALEN-mediated editing of the Mouse Y Chromosome
por: Wang, Haoyi, et al.
Publicado: (2013)

Genome Editing for Crop Improvement – Applications in Clonally Propagated Polyploids With a Focus on Potato (Solanum tuberosum L.)
por: Nadakuduti, Satya Swathi, et al.
Publicado: (2018)

High Efficiency In Vivo Genome Engineering with a Simplified 15-RVD GoldyTALEN Design
por: Ma, Alvin C., et al.
Publicado: (2013)

Mojo Hand, a TALEN design tool for genome editing applications
por: Neff, Kevin L, et al.
Publicado: (2013)

Compact designer TALENs for efficient genome engineering
por: Beurdeley, Marine, et al.
Publicado: (2013)

TALEN‐mediated gene editing of the thrombospondin‐1 locus in axolotl
por: Kuo, Tzu‐Hsing, et al.
Publicado: (2015)

Plant gene editing through de novo induction of meristems
por: Maher, Michael F., et al.
Publicado: (2019)

TALEN-mediated genetic tailoring as a tool to analyze the function of acquired mutations in multiple myeloma cells
por: Wu, X, et al.
Publicado: (2014)

Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways
por: Qi, Yiping, et al.
Publicado: (2013)

Evaluation of Methods to Assess in vivo Activity of Engineered Genome-Editing Nucleases in Protoplasts
por: Nadakuduti, Satya Swathi, et al.
Publicado: (2019)

Genome Editing Using TALENs in Blind Mexican Cavefish, Astyanax mexicanus
por: Ma, Li, et al.
Publicado: (2015)

FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science
por: Ma, Alvin C., et al.
Publicado: (2016)

TAL Effector Specificity for base 0 of the DNA Target Is Altered in a Complex, Effector- and Assay-Dependent Manner by Substitutions for the Tryptophan in Cryptic Repeat –1
por: Doyle, Erin L., et al.
Publicado: (2013)

Building customizable auto-luminescent luciferase-based reporters in plants
por: Khakhar, Arjun, et al.
Publicado: (2020)

Correction: Building customizable auto-luminescent luciferase-based reporters in plants
por: Khakhar, Arjun, et al.
Publicado: (2020)

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
por: Cermak, Tomas, et al.
Publicado: (2011)

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
por: Cermak, Tomas, et al.
Publicado: (2011)

Threshold-dependent repression of SPL gene expression by miR156/miR157 controls vegetative phase change in Arabidopsis thaliana
por: He, Jia, et al.
Publicado: (2018)

Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1
por: Solin, Staci L., et al.
Publicado: (2015)

Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases
por: Qi, Yiping, et al.
Publicado: (2013)

E-TALEN: a web tool to design TALENs for genome engineering
por: Heigwer, Florian, et al.
Publicado: (2013)

Allele exchange at the EPSPS locus confers glyphosate tolerance in cassava
por: Hummel, Aaron W., et al.
Publicado: (2018)

Pigs taking wing with transposons and recombinases
por: Clark, Karl J, et al.
Publicado: (2007)

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
por: Liška, František, et al.
Publicado: (2016)

Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
por: Liška, František, et al.
Publicado: (2020)

Heritable base-editing in Arabidopsis using RNA viral vectors
por: Liu, Degao, et al.
Publicado: (2022)

Lessons from morpholino-based screening in zebrafish
por: Bedell, Victoria M., et al.
Publicado: (2011)

An efficient strategy for TALEN-mediated genome engineering in Drosophila
por: Katsuyama, Tomonori, et al.
Publicado: (2013)

4554 Researchers’ Experiences Working With Community Advisory Boards: How Community Member and Patient Stakeholder Feedback Impacted The Research
por: Brockman, Tabetha A., et al.
Publicado: (2020)

Comparison of TALEN scaffolds in Xenopus tropicalis
por: Nakajima, Keisuke, et al.
Publicado: (2013)

Plant genome editing with TALEN and CRISPR
por: Malzahn, Aimee, et al.
Publicado: (2017)

Targeted gene disruption in somatic zebrafish cells using engineered TALENs
por: Sander, Jeffry D., et al.
Publicado: (2011)

Damaging the Integrated HIV Proviral DNA with TALENs
por: Strong, Christy L., et al.
Publicado: (2015)

TALEN-mediated homologous recombination in Daphnia magna
por: Nakanishi, Takashi, et al.
Publicado: (2015)

Efficient TALEN‐mediated gene editing in wheat
por: Luo, Ming, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_us4ss3cq53bt4q9uktoap7i2il