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The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis

Superior sagittal sinus thrombosis (SSST) is an uncommon cause of stroke, whose symptoms and clinical course are highly variable. It is frequently associated with a variety of hypercoagulable states. Coagulation abnormalities are commonly seen in patients with hyperthyroidism. To the best of our kno...

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Autores principales: Hwang, Jong-Uk, Kwon, Ki-Young, Hur, Jin-Woo, Lee, Jong-Won, Lee, Hyun-Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cerebrovascular Surgeons; Korean Society of Endovascular Surgery 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491224/
https://www.ncbi.nlm.nih.gov/pubmed/23210057
http://dx.doi.org/10.7461/jcen.2012.14.3.251
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author Hwang, Jong-Uk
Kwon, Ki-Young
Hur, Jin-Woo
Lee, Jong-Won
Lee, Hyun-Koo
author_facet Hwang, Jong-Uk
Kwon, Ki-Young
Hur, Jin-Woo
Lee, Jong-Won
Lee, Hyun-Koo
author_sort Hwang, Jong-Uk
collection PubMed
description Superior sagittal sinus thrombosis (SSST) is an uncommon cause of stroke, whose symptoms and clinical course are highly variable. It is frequently associated with a variety of hypercoagulable states. Coagulation abnormalities are commonly seen in patients with hyperthyroidism. To the best of our knowledge, there are few reports on the association between hyperthyroidism and cerebral venous thrombosis. We report on a 31-year-old male patient with a six-year history of hyperthyroidism who developed seizure and mental deterioration. Findings on brain computed tomography (CT) showed multiple hemorrhages in the subcortical area of both middle frontal gyrus and cerebral digital subtraction angiography (DSA) showed irregular intra-luminal filling defects of the superior sagittal sinus. These findings were consistent with hemorrhagic transformation of SSST. Findings on clinical laboratory tests were consistent with hyperthyroidism. In addition, our patient also showed high activity of factors IX and XI. The patient received treatment with oral anticoagulant and prophylthiouracil. His symptoms showed complete improvement. A follow-up cerebral angiography four weeks after treatment showed a recanalization of the SSS. In conclusion, findings of our case indicate that hypercoagulability may contribute to development of SSST in a patient with hyperthyroidism.
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spelling pubmed-34912242012-11-16 The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis Hwang, Jong-Uk Kwon, Ki-Young Hur, Jin-Woo Lee, Jong-Won Lee, Hyun-Koo J Cerebrovasc Endovasc Neurosurg Case Report Superior sagittal sinus thrombosis (SSST) is an uncommon cause of stroke, whose symptoms and clinical course are highly variable. It is frequently associated with a variety of hypercoagulable states. Coagulation abnormalities are commonly seen in patients with hyperthyroidism. To the best of our knowledge, there are few reports on the association between hyperthyroidism and cerebral venous thrombosis. We report on a 31-year-old male patient with a six-year history of hyperthyroidism who developed seizure and mental deterioration. Findings on brain computed tomography (CT) showed multiple hemorrhages in the subcortical area of both middle frontal gyrus and cerebral digital subtraction angiography (DSA) showed irregular intra-luminal filling defects of the superior sagittal sinus. These findings were consistent with hemorrhagic transformation of SSST. Findings on clinical laboratory tests were consistent with hyperthyroidism. In addition, our patient also showed high activity of factors IX and XI. The patient received treatment with oral anticoagulant and prophylthiouracil. His symptoms showed complete improvement. A follow-up cerebral angiography four weeks after treatment showed a recanalization of the SSS. In conclusion, findings of our case indicate that hypercoagulability may contribute to development of SSST in a patient with hyperthyroidism. Korean Society of Cerebrovascular Surgeons; Korean Society of Endovascular Surgery 2012-09 2012-09-28 /pmc/articles/PMC3491224/ /pubmed/23210057 http://dx.doi.org/10.7461/jcen.2012.14.3.251 Text en © 2012 Journal of Cerebrovascular and Endovascular Neurosurgery http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hwang, Jong-Uk
Kwon, Ki-Young
Hur, Jin-Woo
Lee, Jong-Won
Lee, Hyun-Koo
The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis
title The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis
title_full The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis
title_fullStr The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis
title_full_unstemmed The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis
title_short The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis
title_sort role of hyperthyroidism as the predisposing factor for superior sagittal sinus thrombosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491224/
https://www.ncbi.nlm.nih.gov/pubmed/23210057
http://dx.doi.org/10.7461/jcen.2012.14.3.251
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