Cargando…
Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm
In our previous study, the healing effect of proton pump inhibitor plus rebamipide for endoscopic submucosal dissection-related artificial ulcer smaller than 40 mm showed statistical significance. However, such effect of the combination was not yet clear for ulcers with dissected diameter more than...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
the Society for Free Radical Research Japan
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491242/ https://www.ncbi.nlm.nih.gov/pubmed/23170045 http://dx.doi.org/10.3164/jcbn.12-14 |
_version_ | 1782248955463073792 |
---|---|
author | Araki, Hiroshi Kato, Tomohiro Onogi, Fumito Ibuka, Takashi Sugiyama, Akihiko Nakanishi, Takayuki Sugiyama, Tomohiko Tomita, Eiichi Moriwaki, Hisataka |
author_facet | Araki, Hiroshi Kato, Tomohiro Onogi, Fumito Ibuka, Takashi Sugiyama, Akihiko Nakanishi, Takayuki Sugiyama, Tomohiko Tomita, Eiichi Moriwaki, Hisataka |
author_sort | Araki, Hiroshi |
collection | PubMed |
description | In our previous study, the healing effect of proton pump inhibitor plus rebamipide for endoscopic submucosal dissection-related artificial ulcer smaller than 40 mm showed statistical significance. However, such effect of the combination was not yet clear for ulcers with dissected diameter more than 40 mm. The aim of this present study was to resolve this problem under sufficient statistical power, with adequate sample size. We conducted a randomized controlled study. Either the proton pump inhibitor mono-therapy or the combination therapy was prescribed for 28 days after endoscopic submucosal dissection. Eighty-seven patients were eligible for outcome evaluation. Combination therapy was significantly superior to mono-therapy, 27.8% vs 0% reached healing stage (scar stage) in cases with ulcers of dissection diameter more than 40 mm. In conclusion, the combination therapy with rebamipide was favorable regimen in patients with larger artificial ulcer after endoscopic submucosal dissection. |
format | Online Article Text |
id | pubmed-3491242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-34912422012-11-20 Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm Araki, Hiroshi Kato, Tomohiro Onogi, Fumito Ibuka, Takashi Sugiyama, Akihiko Nakanishi, Takayuki Sugiyama, Tomohiko Tomita, Eiichi Moriwaki, Hisataka J Clin Biochem Nutr Original Article In our previous study, the healing effect of proton pump inhibitor plus rebamipide for endoscopic submucosal dissection-related artificial ulcer smaller than 40 mm showed statistical significance. However, such effect of the combination was not yet clear for ulcers with dissected diameter more than 40 mm. The aim of this present study was to resolve this problem under sufficient statistical power, with adequate sample size. We conducted a randomized controlled study. Either the proton pump inhibitor mono-therapy or the combination therapy was prescribed for 28 days after endoscopic submucosal dissection. Eighty-seven patients were eligible for outcome evaluation. Combination therapy was significantly superior to mono-therapy, 27.8% vs 0% reached healing stage (scar stage) in cases with ulcers of dissection diameter more than 40 mm. In conclusion, the combination therapy with rebamipide was favorable regimen in patients with larger artificial ulcer after endoscopic submucosal dissection. the Society for Free Radical Research Japan 2012-11 2012-06-08 /pmc/articles/PMC3491242/ /pubmed/23170045 http://dx.doi.org/10.3164/jcbn.12-14 Text en Copyright © 2012 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Araki, Hiroshi Kato, Tomohiro Onogi, Fumito Ibuka, Takashi Sugiyama, Akihiko Nakanishi, Takayuki Sugiyama, Tomohiko Tomita, Eiichi Moriwaki, Hisataka Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
title | Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
title_full | Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
title_fullStr | Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
title_full_unstemmed | Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
title_short | Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
title_sort | combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491242/ https://www.ncbi.nlm.nih.gov/pubmed/23170045 http://dx.doi.org/10.3164/jcbn.12-14 |
work_keys_str_mv | AT arakihiroshi combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT katotomohiro combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT onogifumito combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT ibukatakashi combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT sugiyamaakihiko combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT nakanishitakayuki combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT sugiyamatomohiko combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT tomitaeiichi combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm AT moriwakihisataka combinationofprotonpumpinhibitorandrebamipideafreeradicalscavengerpromotesartificialulcerhealingafterendoscopicsubmucosaldissectionwithdissectionsize40mm |