Cargando…

Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats

We previously demonstrated that a diet containing fish oil at a level of 80 g/kg strongly stimulated the physiological activity of a sesame sesamin preparation containing sesamin and episesamin at equal amounts to increase hepatic fatty acid oxidation. This study was conducted to clarify whether fis...

Descripción completa

Detalles Bibliográficos
Autor principal: Ide, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491251/
https://www.ncbi.nlm.nih.gov/pubmed/23170054
http://dx.doi.org/10.3164/jcbn.12-38
_version_ 1782248957606363136
author Ide, Takashi
author_facet Ide, Takashi
author_sort Ide, Takashi
collection PubMed
description We previously demonstrated that a diet containing fish oil at a level of 80 g/kg strongly stimulated the physiological activity of a sesame sesamin preparation containing sesamin and episesamin at equal amounts to increase hepatic fatty acid oxidation. This study was conducted to clarify whether fish oil at lower dietary levels enhances the physiological activity of sesamin to increase hepatic fatty acid oxidation. Rats were fed experimental diets supplemented with 0 or 2 g sesamin/kg, and containing 0, 15 or 30 g fish oil/kg for 15 days. Among rats fed sesamin-free diets, diets containing 15 and 30 g fish oil/kg slightly increased the activity of enzymes involved in hepatic fatty acid oxidation. Sesamin increased these values irrespective of the presence or absence of fish oil in diets; however, the extent of the increase of many parameters was much greater in rats given fish oil-containing diets than in those fed a fish oil-free diet. Diets simultaneously containing sesamin and fish oil increased the gene expression of various peroxisomal fatty acid oxidation enzymes in a synergistic manner; but they were ineffective in causing a synergistic increase in mRNA levels of mitochondrial fatty acid oxidation enzymes. The extent of the synergistic increase in the activity of hepatic fatty acid oxidation enzymes and mRNA levels of the peroxisomal enzymes was indistinguishable between diets containing 15 and 30 g fish oil/kg and appeared comparable to that observed previously with a diet containing 80 g fish oil/kg.
format Online
Article
Text
id pubmed-3491251
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher the Society for Free Radical Research Japan
record_format MEDLINE/PubMed
spelling pubmed-34912512012-11-20 Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats Ide, Takashi J Clin Biochem Nutr Original Article We previously demonstrated that a diet containing fish oil at a level of 80 g/kg strongly stimulated the physiological activity of a sesame sesamin preparation containing sesamin and episesamin at equal amounts to increase hepatic fatty acid oxidation. This study was conducted to clarify whether fish oil at lower dietary levels enhances the physiological activity of sesamin to increase hepatic fatty acid oxidation. Rats were fed experimental diets supplemented with 0 or 2 g sesamin/kg, and containing 0, 15 or 30 g fish oil/kg for 15 days. Among rats fed sesamin-free diets, diets containing 15 and 30 g fish oil/kg slightly increased the activity of enzymes involved in hepatic fatty acid oxidation. Sesamin increased these values irrespective of the presence or absence of fish oil in diets; however, the extent of the increase of many parameters was much greater in rats given fish oil-containing diets than in those fed a fish oil-free diet. Diets simultaneously containing sesamin and fish oil increased the gene expression of various peroxisomal fatty acid oxidation enzymes in a synergistic manner; but they were ineffective in causing a synergistic increase in mRNA levels of mitochondrial fatty acid oxidation enzymes. The extent of the synergistic increase in the activity of hepatic fatty acid oxidation enzymes and mRNA levels of the peroxisomal enzymes was indistinguishable between diets containing 15 and 30 g fish oil/kg and appeared comparable to that observed previously with a diet containing 80 g fish oil/kg. the Society for Free Radical Research Japan 2012-11 2012-10-31 /pmc/articles/PMC3491251/ /pubmed/23170054 http://dx.doi.org/10.3164/jcbn.12-38 Text en Copyright © 2012 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ide, Takashi
Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
title Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
title_full Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
title_fullStr Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
title_full_unstemmed Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
title_short Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
title_sort fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491251/
https://www.ncbi.nlm.nih.gov/pubmed/23170054
http://dx.doi.org/10.3164/jcbn.12-38
work_keys_str_mv AT idetakashi fishoilatlowdietarylevelsenhancesphysiologicalactivityofsesamintoincreasehepaticfattyacidoxidationinrats