The birth of the Epitranscriptome: deciphering the function of RNA modifications

Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.

Detalles Bibliográficos
Autores principales: Saletore, Yogesh, Meyer, Kate, Korlach, Jonas, Vilfan, Igor D, Jaffrey, Samie, Mason, Christopher E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491402/
https://www.ncbi.nlm.nih.gov/pubmed/23113984
http://dx.doi.org/10.1186/gb-2012-13-10-175
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author Saletore, Yogesh
Meyer, Kate
Korlach, Jonas
Vilfan, Igor D
Jaffrey, Samie
Mason, Christopher E
author_facet Saletore, Yogesh
Meyer, Kate
Korlach, Jonas
Vilfan, Igor D
Jaffrey, Samie
Mason, Christopher E
author_sort Saletore, Yogesh
collection PubMed
description Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.
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spelling pubmed-34914022013-10-31 The birth of the Epitranscriptome: deciphering the function of RNA modifications Saletore, Yogesh Meyer, Kate Korlach, Jonas Vilfan, Igor D Jaffrey, Samie Mason, Christopher E Genome Biol Opinion Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications. BioMed Central 2012 2012-10-31 /pmc/articles/PMC3491402/ /pubmed/23113984 http://dx.doi.org/10.1186/gb-2012-13-10-175 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Opinion
Saletore, Yogesh
Meyer, Kate
Korlach, Jonas
Vilfan, Igor D
Jaffrey, Samie
Mason, Christopher E
The birth of the Epitranscriptome: deciphering the function of RNA modifications
title The birth of the Epitranscriptome: deciphering the function of RNA modifications
title_full The birth of the Epitranscriptome: deciphering the function of RNA modifications
title_fullStr The birth of the Epitranscriptome: deciphering the function of RNA modifications
title_full_unstemmed The birth of the Epitranscriptome: deciphering the function of RNA modifications
title_short The birth of the Epitranscriptome: deciphering the function of RNA modifications
title_sort birth of the epitranscriptome: deciphering the function of rna modifications
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491402/
https://www.ncbi.nlm.nih.gov/pubmed/23113984
http://dx.doi.org/10.1186/gb-2012-13-10-175
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