The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation

Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.

Detalles Bibliográficos
Autores principales: Schmidt, Ryan, Plath, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491406/
https://www.ncbi.nlm.nih.gov/pubmed/23088445
http://dx.doi.org/10.1186/gb-2012-13-10-251
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author Schmidt, Ryan
Plath, Kathrin
author_facet Schmidt, Ryan
Plath, Kathrin
author_sort Schmidt, Ryan
collection PubMed
description Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.
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spelling pubmed-34914062013-10-22 The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation Schmidt, Ryan Plath, Kathrin Genome Biol Review Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome. BioMed Central 2012 2012-10-22 /pmc/articles/PMC3491406/ /pubmed/23088445 http://dx.doi.org/10.1186/gb-2012-13-10-251 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Review
Schmidt, Ryan
Plath, Kathrin
The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
title The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
title_full The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
title_fullStr The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
title_full_unstemmed The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
title_short The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
title_sort roles of the reprogramming factors oct4, sox2 and klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491406/
https://www.ncbi.nlm.nih.gov/pubmed/23088445
http://dx.doi.org/10.1186/gb-2012-13-10-251
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