The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation

Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.

Detalles Bibliográficos
Autores principales: Schmidt, Ryan, Plath, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491406/
https://www.ncbi.nlm.nih.gov/pubmed/23088445
http://dx.doi.org/10.1186/gb-2012-13-10-251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491406/
https://www.ncbi.nlm.nih.gov/pubmed/23088445
http://dx.doi.org/10.1186/gb-2012-13-10-251

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