miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

Bile secretion is essential for whole body sterol homeostasis. Loss-of-function mutations in specific canalicular transporters in the hepatocyte disrupt bile flow and result in cholestasis. We show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that...

Descripción completa

Detalles Bibliográficos
Autores principales: Allen, Ryan M, Marquart, Tyler J, Albert, Carolyn J, Suchy, Frederick J, Wang, David Q-H, Ananthanarayanan, Meenakshisundaram, Ford, David A, Baldán, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491822/
https://www.ncbi.nlm.nih.gov/pubmed/22767443
http://dx.doi.org/10.1002/emmm.201201228

Ejemplares similares

Ejemplares similares