β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

β-Secretase (BACE1) is a major drug target for combating Alzheimer's disease (AD). Here we show that BACE1(−/−) mice develop significant retinal pathology including retinal thinning, apoptosis, reduced retinal vascular density and an increase in the age pigment, lipofuscin. BACE1 expression is...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Jun, Qi, Xiaoping, Kociok, Norbert, Skosyrski, Sergej, Emilio, Alonso, Ruan, Qing, Han, Song, Liu, Li, Chen, Zhijuan, Bowes Rickman, Catherine, Golde, Todd, Grant, Maria B, Saftig, Paul, Serneels, Lutgarde, de Strooper, Bart, Joussen, Antonia M, Boulton, Michael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491829/
https://www.ncbi.nlm.nih.gov/pubmed/22903875
http://dx.doi.org/10.1002/emmm.201101084

Ejemplares similares

Ejemplares similares