A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation

T lymphocytes exhibit pro-inflammatory or anti-inflammatory activities in obesity and diabetes, depending on their subtypes. Guanidine-rich immunosuppressive oligodeoxynucleotides (ODNs) effectively control Th1/Th2-cell counterbalance. This study reveals a non-toxic regulatory ODN (ODNR01) that inhi...

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Detalles Bibliográficos
Autores principales: Cheng, Xiang, Wang, Jing, Xia, Ni, Yan, Xin-Xin, Tang, Ting-Ting, Chen, Han, Zhang, Hong-Jian, Liu, Juan, Kong, Wen, Sjöberg, Sara, Folco, Eduardo, Libby, Peter, Liao, Yu-Hua, Shi, Guo-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491840/
https://www.ncbi.nlm.nih.gov/pubmed/23027613
http://dx.doi.org/10.1002/emmm.201201272

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