The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice

Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti-leishmanial agent. The compound induces topoisomerase I-mediated DNA–prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Chowdhury, Sayan, Mukherjee, Tulika, Mukhopadhyay, Rupkatha, Mukherjee, Budhaditya, Sengupta, Souvik, Chattopadhyay, Sharmila, Jaisankar, Parasuraman, Roy, Syamal, Majumder, Hemanta K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491841/
https://www.ncbi.nlm.nih.gov/pubmed/23027614
http://dx.doi.org/10.1002/emmm.201201316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491841/
https://www.ncbi.nlm.nih.gov/pubmed/23027614
http://dx.doi.org/10.1002/emmm.201201316

Ejemplares similares