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The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice

Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti-leishmanial agent. The compound induces topoisomerase I-mediated DNA–prot...

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Detalles Bibliográficos
Autores principales:	Chowdhury, Sayan, Mukherjee, Tulika, Mukhopadhyay, Rupkatha, Mukherjee, Budhaditya, Sengupta, Souvik, Chattopadhyay, Sharmila, Jaisankar, Parasuraman, Roy, Syamal, Majumder, Hemanta K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491841/ https://www.ncbi.nlm.nih.gov/pubmed/23027614 http://dx.doi.org/10.1002/emmm.201201316

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