Cargando…
Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
BACKGROUND: The use of mechanical cardiopulmonary resuscitation (CPR) has great potential for the clinical setting. The purpose of present study is to compare the hemodynamics and ventilation during and after the load-distributing band CPR, versus the manual CPR in a porcine model of prolonged cardi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492085/ https://www.ncbi.nlm.nih.gov/pubmed/22938018 http://dx.doi.org/10.1186/1757-7241-20-59 |
_version_ | 1782249053251174400 |
---|---|
author | Wang, Shuo Wu, Jun-Yuan Li, Chun-Sheng |
author_facet | Wang, Shuo Wu, Jun-Yuan Li, Chun-Sheng |
author_sort | Wang, Shuo |
collection | PubMed |
description | BACKGROUND: The use of mechanical cardiopulmonary resuscitation (CPR) has great potential for the clinical setting. The purpose of present study is to compare the hemodynamics and ventilation during and after the load-distributing band CPR, versus the manual CPR in a porcine model of prolonged cardiac arrest, and to investigate the influence of rescue breathing in different CPR protocols. METHODS: Sixty-four male pigs (n = 16/group), weighing 30 ± 2 kg, were induced ventricular fibrillation and randomized into four resuscitation groups: continuous load-distributing band CPR without rescue ventilation (C-CPR), load-distributing band 30:2 CPR (A-CPR), load-distributing band CPR with continuous rescue breathing (10/min) (V-CPR) or manual 30:2 CPR (M-CPR). Respiratory variables and hemodynamics were recorded continuously; blood gas was analyzed. RESULTS: Tidal volume produced by compressions in the A-, C- and V-CPR groups were significantly higher compared with the M-CPR group (all p < 0.05). Coronary perfusion pressure of the V-CPR group was significantly lower than the C-CPR group (p < 0.01), but higher than the M-CPR group. The increasing of lung dead space after restoration of spontaneous circulation was significantly greater in the M-CPR group compared with the A-, C- and V-CPR groups (p < 0.01). Blood pH gradually decreased and was lower in the M-CPR group than that in the A-, C- and V-CPR groups (p < 0.01). PaO(2) of the A-, C- and V-CPR groups were significantly higher and PaCO(2) were significantly lower compared with the M-CPR (both p < 0.05). Cerebral performance categories were better in the A-, C- and V-CPR groups compared with the M-CPR group (p < 0.0001). CONCLUSIONS: The load-distributing band CPR significantly improved respiratory parameters during resuscitation by augmenting passive ventilation, and significantly improved coronary perfusion pressure. The volume of ventilation produced by the load-distributing band CPR was adequate to maintain sufficient gas exchange independent of rescue breathing. |
format | Online Article Text |
id | pubmed-3492085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34920852012-11-09 Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest Wang, Shuo Wu, Jun-Yuan Li, Chun-Sheng Scand J Trauma Resusc Emerg Med Original Research BACKGROUND: The use of mechanical cardiopulmonary resuscitation (CPR) has great potential for the clinical setting. The purpose of present study is to compare the hemodynamics and ventilation during and after the load-distributing band CPR, versus the manual CPR in a porcine model of prolonged cardiac arrest, and to investigate the influence of rescue breathing in different CPR protocols. METHODS: Sixty-four male pigs (n = 16/group), weighing 30 ± 2 kg, were induced ventricular fibrillation and randomized into four resuscitation groups: continuous load-distributing band CPR without rescue ventilation (C-CPR), load-distributing band 30:2 CPR (A-CPR), load-distributing band CPR with continuous rescue breathing (10/min) (V-CPR) or manual 30:2 CPR (M-CPR). Respiratory variables and hemodynamics were recorded continuously; blood gas was analyzed. RESULTS: Tidal volume produced by compressions in the A-, C- and V-CPR groups were significantly higher compared with the M-CPR group (all p < 0.05). Coronary perfusion pressure of the V-CPR group was significantly lower than the C-CPR group (p < 0.01), but higher than the M-CPR group. The increasing of lung dead space after restoration of spontaneous circulation was significantly greater in the M-CPR group compared with the A-, C- and V-CPR groups (p < 0.01). Blood pH gradually decreased and was lower in the M-CPR group than that in the A-, C- and V-CPR groups (p < 0.01). PaO(2) of the A-, C- and V-CPR groups were significantly higher and PaCO(2) were significantly lower compared with the M-CPR (both p < 0.05). Cerebral performance categories were better in the A-, C- and V-CPR groups compared with the M-CPR group (p < 0.0001). CONCLUSIONS: The load-distributing band CPR significantly improved respiratory parameters during resuscitation by augmenting passive ventilation, and significantly improved coronary perfusion pressure. The volume of ventilation produced by the load-distributing band CPR was adequate to maintain sufficient gas exchange independent of rescue breathing. BioMed Central 2012-09-01 /pmc/articles/PMC3492085/ /pubmed/22938018 http://dx.doi.org/10.1186/1757-7241-20-59 Text en Copyright ©2012 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Wang, Shuo Wu, Jun-Yuan Li, Chun-Sheng Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
title | Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
title_full | Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
title_fullStr | Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
title_full_unstemmed | Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
title_short | Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
title_sort | load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492085/ https://www.ncbi.nlm.nih.gov/pubmed/22938018 http://dx.doi.org/10.1186/1757-7241-20-59 |
work_keys_str_mv | AT wangshuo loaddistributingbandimprovesventilationandhemodynamicsduringresuscitationinaporcinemodelofprolongedcardiacarrest AT wujunyuan loaddistributingbandimprovesventilationandhemodynamicsduringresuscitationinaporcinemodelofprolongedcardiacarrest AT lichunsheng loaddistributingbandimprovesventilationandhemodynamicsduringresuscitationinaporcinemodelofprolongedcardiacarrest |