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Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest

BACKGROUND: The use of mechanical cardiopulmonary resuscitation (CPR) has great potential for the clinical setting. The purpose of present study is to compare the hemodynamics and ventilation during and after the load-distributing band CPR, versus the manual CPR in a porcine model of prolonged cardi...

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Autores principales: Wang, Shuo, Wu, Jun-Yuan, Li, Chun-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492085/
https://www.ncbi.nlm.nih.gov/pubmed/22938018
http://dx.doi.org/10.1186/1757-7241-20-59
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author Wang, Shuo
Wu, Jun-Yuan
Li, Chun-Sheng
author_facet Wang, Shuo
Wu, Jun-Yuan
Li, Chun-Sheng
author_sort Wang, Shuo
collection PubMed
description BACKGROUND: The use of mechanical cardiopulmonary resuscitation (CPR) has great potential for the clinical setting. The purpose of present study is to compare the hemodynamics and ventilation during and after the load-distributing band CPR, versus the manual CPR in a porcine model of prolonged cardiac arrest, and to investigate the influence of rescue breathing in different CPR protocols. METHODS: Sixty-four male pigs (n = 16/group), weighing 30 ± 2 kg, were induced ventricular fibrillation and randomized into four resuscitation groups: continuous load-distributing band CPR without rescue ventilation (C-CPR), load-distributing band 30:2 CPR (A-CPR), load-distributing band CPR with continuous rescue breathing (10/min) (V-CPR) or manual 30:2 CPR (M-CPR). Respiratory variables and hemodynamics were recorded continuously; blood gas was analyzed. RESULTS: Tidal volume produced by compressions in the A-, C- and V-CPR groups were significantly higher compared with the M-CPR group (all p < 0.05). Coronary perfusion pressure of the V-CPR group was significantly lower than the C-CPR group (p < 0.01), but higher than the M-CPR group. The increasing of lung dead space after restoration of spontaneous circulation was significantly greater in the M-CPR group compared with the A-, C- and V-CPR groups (p < 0.01). Blood pH gradually decreased and was lower in the M-CPR group than that in the A-, C- and V-CPR groups (p < 0.01). PaO(2) of the A-, C- and V-CPR groups were significantly higher and PaCO(2) were significantly lower compared with the M-CPR (both p < 0.05). Cerebral performance categories were better in the A-, C- and V-CPR groups compared with the M-CPR group (p < 0.0001). CONCLUSIONS: The load-distributing band CPR significantly improved respiratory parameters during resuscitation by augmenting passive ventilation, and significantly improved coronary perfusion pressure. The volume of ventilation produced by the load-distributing band CPR was adequate to maintain sufficient gas exchange independent of rescue breathing.
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spelling pubmed-34920852012-11-09 Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest Wang, Shuo Wu, Jun-Yuan Li, Chun-Sheng Scand J Trauma Resusc Emerg Med Original Research BACKGROUND: The use of mechanical cardiopulmonary resuscitation (CPR) has great potential for the clinical setting. The purpose of present study is to compare the hemodynamics and ventilation during and after the load-distributing band CPR, versus the manual CPR in a porcine model of prolonged cardiac arrest, and to investigate the influence of rescue breathing in different CPR protocols. METHODS: Sixty-four male pigs (n = 16/group), weighing 30 ± 2 kg, were induced ventricular fibrillation and randomized into four resuscitation groups: continuous load-distributing band CPR without rescue ventilation (C-CPR), load-distributing band 30:2 CPR (A-CPR), load-distributing band CPR with continuous rescue breathing (10/min) (V-CPR) or manual 30:2 CPR (M-CPR). Respiratory variables and hemodynamics were recorded continuously; blood gas was analyzed. RESULTS: Tidal volume produced by compressions in the A-, C- and V-CPR groups were significantly higher compared with the M-CPR group (all p < 0.05). Coronary perfusion pressure of the V-CPR group was significantly lower than the C-CPR group (p < 0.01), but higher than the M-CPR group. The increasing of lung dead space after restoration of spontaneous circulation was significantly greater in the M-CPR group compared with the A-, C- and V-CPR groups (p < 0.01). Blood pH gradually decreased and was lower in the M-CPR group than that in the A-, C- and V-CPR groups (p < 0.01). PaO(2) of the A-, C- and V-CPR groups were significantly higher and PaCO(2) were significantly lower compared with the M-CPR (both p < 0.05). Cerebral performance categories were better in the A-, C- and V-CPR groups compared with the M-CPR group (p < 0.0001). CONCLUSIONS: The load-distributing band CPR significantly improved respiratory parameters during resuscitation by augmenting passive ventilation, and significantly improved coronary perfusion pressure. The volume of ventilation produced by the load-distributing band CPR was adequate to maintain sufficient gas exchange independent of rescue breathing. BioMed Central 2012-09-01 /pmc/articles/PMC3492085/ /pubmed/22938018 http://dx.doi.org/10.1186/1757-7241-20-59 Text en Copyright ©2012 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Wang, Shuo
Wu, Jun-Yuan
Li, Chun-Sheng
Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
title Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
title_full Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
title_fullStr Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
title_full_unstemmed Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
title_short Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
title_sort load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492085/
https://www.ncbi.nlm.nih.gov/pubmed/22938018
http://dx.doi.org/10.1186/1757-7241-20-59
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