Serological evidence of ebolavirus infection in bats, China

BACKGROUND: The genus Ebolavirus of the family Filoviridae currently consists of five species. All species, with the exception of Reston ebolavirus, have been found in Africa and caused severe human diseases. Bats have been implicated as reservoirs for ebolavirus. Reston ebolavirus, discovered in th...

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Autores principales: Yuan, Junfa, Zhang, Yuji, Li, Jialu, Zhang, Yunzhi, Wang, Lin-Fa, Shi, Zhengli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492202/
https://www.ncbi.nlm.nih.gov/pubmed/23062147
http://dx.doi.org/10.1186/1743-422X-9-236
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author Yuan, Junfa
Zhang, Yuji
Li, Jialu
Zhang, Yunzhi
Wang, Lin-Fa
Shi, Zhengli
author_facet Yuan, Junfa
Zhang, Yuji
Li, Jialu
Zhang, Yunzhi
Wang, Lin-Fa
Shi, Zhengli
author_sort Yuan, Junfa
collection PubMed
description BACKGROUND: The genus Ebolavirus of the family Filoviridae currently consists of five species. All species, with the exception of Reston ebolavirus, have been found in Africa and caused severe human diseases. Bats have been implicated as reservoirs for ebolavirus. Reston ebolavirus, discovered in the Philippines, is the only ebolavirus species identified in Asia to date. Whether this virus is prevalent in China is unknown. FINDINGS: In this study, we developed an enzyme linked immunosorbent assay (ELISA) for ebolavirus using the recombinant nucleocapsid protein and performed sero-surveillance for the virus among Chinese bat populations. Our results revealed the presence of antibodies to ebolavirus in 32 of 843 bat sera samples and 10 of 16 were further confirmed by western blot analysis. CONCLUSION: To our knowledge, this is the first report of any filovirus infection in China.
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spelling pubmed-34922022012-11-08 Serological evidence of ebolavirus infection in bats, China Yuan, Junfa Zhang, Yuji Li, Jialu Zhang, Yunzhi Wang, Lin-Fa Shi, Zhengli Virol J Short Report BACKGROUND: The genus Ebolavirus of the family Filoviridae currently consists of five species. All species, with the exception of Reston ebolavirus, have been found in Africa and caused severe human diseases. Bats have been implicated as reservoirs for ebolavirus. Reston ebolavirus, discovered in the Philippines, is the only ebolavirus species identified in Asia to date. Whether this virus is prevalent in China is unknown. FINDINGS: In this study, we developed an enzyme linked immunosorbent assay (ELISA) for ebolavirus using the recombinant nucleocapsid protein and performed sero-surveillance for the virus among Chinese bat populations. Our results revealed the presence of antibodies to ebolavirus in 32 of 843 bat sera samples and 10 of 16 were further confirmed by western blot analysis. CONCLUSION: To our knowledge, this is the first report of any filovirus infection in China. BioMed Central 2012-10-13 /pmc/articles/PMC3492202/ /pubmed/23062147 http://dx.doi.org/10.1186/1743-422X-9-236 Text en Copyright ©2012 Yuan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Yuan, Junfa
Zhang, Yuji
Li, Jialu
Zhang, Yunzhi
Wang, Lin-Fa
Shi, Zhengli
Serological evidence of ebolavirus infection in bats, China
title Serological evidence of ebolavirus infection in bats, China
title_full Serological evidence of ebolavirus infection in bats, China
title_fullStr Serological evidence of ebolavirus infection in bats, China
title_full_unstemmed Serological evidence of ebolavirus infection in bats, China
title_short Serological evidence of ebolavirus infection in bats, China
title_sort serological evidence of ebolavirus infection in bats, china
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492202/
https://www.ncbi.nlm.nih.gov/pubmed/23062147
http://dx.doi.org/10.1186/1743-422X-9-236
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