Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging

Small non-coding microRNAs are believed to be involved in the mechanism of aging but nothing is known on the impact of microRNAs in the progeroid disorder Werner syndrome (WS). WS is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the W...

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Detalles Bibliográficos
Autores principales: Dallaire, Alexandra, Garand, Chantal, Paquet, Eric R., Mitchell, Sarah J., de Cabo, Rafael, Simard, Martin J., Lebel, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492227/
https://www.ncbi.nlm.nih.gov/pubmed/23075628

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