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Lentiviral Transduction of CD34(+) Cells Induces Genome-Wide Epigenetic Modifications

Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols. In an experimental model of ex vivo gene modification for hematopoietic gene therapy, human CD34(+) cells were cultured shortly...

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Detalles Bibliográficos
Autores principales:	Yamagata, Yoshiaki, Parietti, Véronique, Stockholm, Daniel, Corre, Guillaume, Poinsignon, Catherine, Touleimat, Nizar, Delafoy, Damien, Besse, Céline, Tost, Jörg, Galy, Anne, Paldi, András
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492239/ https://www.ncbi.nlm.nih.gov/pubmed/23145033 http://dx.doi.org/10.1371/journal.pone.0048943

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