Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro

Drug distribution in cells is a fundamentally important, yet often overlooked, variable in drug efficacy. Many weakly basic anticancer agents accumulate extensively in the acidic lysosomes of normal cells through ion trapping. Lysosomal trapping reduces the activity of anticancer drugs, since antica...

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Detalles Bibliográficos
Autores principales: Ndolo, Rosemary A., Luan, Yepeng, Duan, Shaofeng, Forrest, M. Laird, Krise, Jeffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492287/
https://www.ncbi.nlm.nih.gov/pubmed/23145164
http://dx.doi.org/10.1371/journal.pone.0049366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492287/
https://www.ncbi.nlm.nih.gov/pubmed/23145164
http://dx.doi.org/10.1371/journal.pone.0049366

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