Cargando…

Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma

BACKGROUND: Osteosarcomas are the most common non-haematological primary malignant tumours of bone, and all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kresse, Stine H., Rydbeck, Halfdan, Skårn, Magne, Namløs, Heidi M., Barragan-Polania, Ana H., Cleton-Jansen, Anne-Marie, Serra, Massimo, Liestøl, Knut, Hogendoorn, Pancras C. W., Hovig, Eivind, Myklebost, Ola, Meza-Zepeda, Leonardo A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492335/ https://www.ncbi.nlm.nih.gov/pubmed/23144859 http://dx.doi.org/10.1371/journal.pone.0048262

Ejemplares similares

Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
por: Kresse, Stine H, et al.
Publicado: (2010)

mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
por: Kuijjer, Marieke L, et al.
Publicado: (2011)

DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
por: Kresse, Stine H, et al.
Publicado: (2008)

miR-486-5p expression is regulated by DNA methylation in osteosarcoma
por: Namløs, Heidi M., et al.
Publicado: (2022)

Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs
por: Namløs, Heidi M., et al.
Publicado: (2012)

Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
por: Barøy, Tale, et al.
Publicado: (2014)

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
por: Kuijjer, Marieke L, et al.
Publicado: (2013)

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
por: Lauvrak, S U, et al.
Publicado: (2013)

Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples
por: Kresse, Stine H., et al.
Publicado: (2018)

Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
por: Namløs, Heidi M., et al.
Publicado: (2017)

Chromosomal instability and a deregulated cell cycle are intrinsic features of high‐risk gastrointestinal stromal tumours with a metastatic potential
por: Namløs, Heidi Maria, et al.
Publicado: (2023)

Osteosarcoma Models: From Cell Lines to Zebrafish
por: Mohseny, Alexander B., et al.
Publicado: (2012)

M-CGH: Analysing microarray-based CGH experiments
por: Wang, Junbai, et al.
Publicado: (2004)

Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern
por: Namløs, Heidi M., et al.
Publicado: (2012)

DNA Copy Number Changes in Human Malignant Fibrous Histiocytomas by Array Comparative Genomic Hybridisation
por: Kresse, Stine H., et al.
Publicado: (2010)

The Genomic HyperBrowser: inferential genomics at the sequence level
por: Sandve, Geir K, et al.
Publicado: (2010)

Epigenetic Regulation and Functional Characterization of MicroRNA-142 in Mesenchymal Cells
por: Skårn, Magne, et al.
Publicado: (2013)

ClusTrack: Feature Extraction and Similarity Measures for Clustering of Genome-Wide Data Sets
por: Rydbeck, Halfdan, et al.
Publicado: (2015)

The differential disease regulome
por: Sandve, Geir K, et al.
Publicado: (2011)

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
por: Sarver, Aaron L, et al.
Publicado: (2013)

Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy
por: Kuijjer, Marieke L, et al.
Publicado: (2014)

Performance comparison of four exome capture systems for deep sequencing
por: Chilamakuri, Chandra Sekhar Reddy, et al.
Publicado: (2014)

Sample-Index Misassignment Impacts Tumour Exome Sequencing
por: Vodák, Daniel, et al.
Publicado: (2018)

Characterization of Liposarcoma Cell Lines for Preclinical and Biological Studies
por: Stratford, Eva W., et al.
Publicado: (2012)

Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
por: Hjortland, Geir Olav, et al.
Publicado: (2011)

Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
por: Kresse, Stine H, et al.
Publicado: (2005)

GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
por: Lyng, Heidi, et al.
Publicado: (2008)

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
por: Baranski, Zuzanna, et al.
Publicado: (2015)

Mesenchymal stem cell transformation and sarcoma genesis
por: Xiao, Wei, et al.
Publicado: (2013)

MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation
por: Baranski, Zuzanna, et al.
Publicado: (2015)

Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
por: Lyng, Heidi, et al.
Publicado: (2004)

Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data
por: Wang, Junbai, et al.
Publicado: (2003)

Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo
por: Meijer, Danielle, et al.
Publicado: (2011)

Limitations of mRNA amplification from small-size cell samples
por: Nygaard, Vigdis, et al.
Publicado: (2005)

Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture
por: Buddingh, Emilie P, et al.
Publicado: (2015)

Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
por: Barøy, Tale, et al.
Publicado: (2016)

The Genomic HyperBrowser: an analysis web server for genome-scale data
por: Sandve, Geir K., et al.
Publicado: (2013)

TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
por: Halvorsen, Ann R., et al.
Publicado: (2016)

Personal Cancer Genome Reporter: variant interpretation report for precision oncology
por: Nakken, Sigve, et al.
Publicado: (2018)

Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report
por: Lilleby, Wolfgang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_c9hrbs2ngdfcusu116d6lkpv0r