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Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months

Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12...

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Autores principales: Kim, Hyo-Bin, Ahn, Kang Mo, Kim, Kyung Won, Shin, Youn Ho, Yu, Jinho, Seo, Ju-Hee, Kim, Hyung Young, Kwon, Ji-Won, Kim, Byoung-Ju, Kwon, Ja-Young, Choi, Suk-Joo, Lee, Kyung-Ju, Park, Hee Jin, Won, Hye-Sung, Hong, Soo-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492665/
https://www.ncbi.nlm.nih.gov/pubmed/23166412
http://dx.doi.org/10.3346/jkms.2012.27.11.1320
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author Kim, Hyo-Bin
Ahn, Kang Mo
Kim, Kyung Won
Shin, Youn Ho
Yu, Jinho
Seo, Ju-Hee
Kim, Hyung Young
Kwon, Ji-Won
Kim, Byoung-Ju
Kwon, Ja-Young
Choi, Suk-Joo
Lee, Kyung-Ju
Park, Hee Jin
Won, Hye-Sung
Hong, Soo-Jong
author_facet Kim, Hyo-Bin
Ahn, Kang Mo
Kim, Kyung Won
Shin, Youn Ho
Yu, Jinho
Seo, Ju-Hee
Kim, Hyung Young
Kwon, Ji-Won
Kim, Byoung-Ju
Kwon, Ja-Young
Choi, Suk-Joo
Lee, Kyung-Ju
Park, Hee Jin
Won, Hye-Sung
Hong, Soo-Jong
author_sort Kim, Hyo-Bin
collection PubMed
description Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-γ, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months.
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spelling pubmed-34926652012-11-19 Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months Kim, Hyo-Bin Ahn, Kang Mo Kim, Kyung Won Shin, Youn Ho Yu, Jinho Seo, Ju-Hee Kim, Hyung Young Kwon, Ji-Won Kim, Byoung-Ju Kwon, Ja-Young Choi, Suk-Joo Lee, Kyung-Ju Park, Hee Jin Won, Hye-Sung Hong, Soo-Jong J Korean Med Sci Original Article Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-γ, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months. The Korean Academy of Medical Sciences 2012-11 2012-10-30 /pmc/articles/PMC3492665/ /pubmed/23166412 http://dx.doi.org/10.3346/jkms.2012.27.11.1320 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyo-Bin
Ahn, Kang Mo
Kim, Kyung Won
Shin, Youn Ho
Yu, Jinho
Seo, Ju-Hee
Kim, Hyung Young
Kwon, Ji-Won
Kim, Byoung-Ju
Kwon, Ja-Young
Choi, Suk-Joo
Lee, Kyung-Ju
Park, Hee Jin
Won, Hye-Sung
Hong, Soo-Jong
Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
title Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
title_full Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
title_fullStr Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
title_full_unstemmed Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
title_short Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
title_sort cord blood cellular proliferative response as a predictive factor for atopic dermatitis at 12 months
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492665/
https://www.ncbi.nlm.nih.gov/pubmed/23166412
http://dx.doi.org/10.3346/jkms.2012.27.11.1320
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