Cargando…
Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
This study was performed to compare clinical and imaging parameters and prognosis of unprovoked pulmonary embolism (PE), provoked PE with reversible risk factors (provoked-rRF), and provoked PE with irreversible risk factors (provoked-iRF) in Koreans. Three hundred consecutive patients (mean age, 63...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492669/ https://www.ncbi.nlm.nih.gov/pubmed/23166416 http://dx.doi.org/10.3346/jkms.2012.27.11.1347 |
_version_ | 1782249153214021632 |
---|---|
author | Uhm, Jae-Sun Jung, Hae-Ok Kim, Chan-Joon Kim, Tae-Hoon Youn, Ho-Joong Baek, Sang Hong Chung, Wook-Sung Seung, Ki Bae |
author_facet | Uhm, Jae-Sun Jung, Hae-Ok Kim, Chan-Joon Kim, Tae-Hoon Youn, Ho-Joong Baek, Sang Hong Chung, Wook-Sung Seung, Ki Bae |
author_sort | Uhm, Jae-Sun |
collection | PubMed |
description | This study was performed to compare clinical and imaging parameters and prognosis of unprovoked pulmonary embolism (PE), provoked PE with reversible risk factors (provoked-rRF), and provoked PE with irreversible risk factors (provoked-iRF) in Koreans. Three hundred consecutive patients (mean age, 63.6 ± 15.0 yr; 42.8% male) diagnosed with acute PE were included. The patients were classified into 3 groups; unprovoked PE, provoked-rRF, and provoked-iRF; 43.7%, 14.7%, and 41.7%, respectively. We followed up the patients for 25.4 ± 33.7 months. Composite endpoint was all-cause mortality and recurrent PE. The provoked-iRF group had significantly higher all-cause mortality, mortality from PE and recurrent PE than the unprovoked and provoked-rRF groups (P < 0.001, P < 0.001, and P = 0.034, respectively). Prognostic factors of composite endpoint in the unprovoked group were high creatinine (> 1.2 mg/dL; P < 0.001; hazard ratio [HR], 4.735; 95% confidence interval [CI], 1.845-12.152), C-reactive protein (CRP; > 5 mg/L; P = 0.002; HR, 5.308; 95% CI, 1.824-15.447) and computed tomography (CT) obstruction index (P = 0.034; HR, 1.090; 95% CI, 1.006-1.181). In conclusion, provoked-iRF has a poorer prognosis than unprovoked PE and provoked-rRF. Renal insufficiency, high CRP, and CT obstruction index are poor prognostic factors in unprovoked PE. |
format | Online Article Text |
id | pubmed-3492669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-34926692012-11-19 Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans Uhm, Jae-Sun Jung, Hae-Ok Kim, Chan-Joon Kim, Tae-Hoon Youn, Ho-Joong Baek, Sang Hong Chung, Wook-Sung Seung, Ki Bae J Korean Med Sci Original Article This study was performed to compare clinical and imaging parameters and prognosis of unprovoked pulmonary embolism (PE), provoked PE with reversible risk factors (provoked-rRF), and provoked PE with irreversible risk factors (provoked-iRF) in Koreans. Three hundred consecutive patients (mean age, 63.6 ± 15.0 yr; 42.8% male) diagnosed with acute PE were included. The patients were classified into 3 groups; unprovoked PE, provoked-rRF, and provoked-iRF; 43.7%, 14.7%, and 41.7%, respectively. We followed up the patients for 25.4 ± 33.7 months. Composite endpoint was all-cause mortality and recurrent PE. The provoked-iRF group had significantly higher all-cause mortality, mortality from PE and recurrent PE than the unprovoked and provoked-rRF groups (P < 0.001, P < 0.001, and P = 0.034, respectively). Prognostic factors of composite endpoint in the unprovoked group were high creatinine (> 1.2 mg/dL; P < 0.001; hazard ratio [HR], 4.735; 95% confidence interval [CI], 1.845-12.152), C-reactive protein (CRP; > 5 mg/L; P = 0.002; HR, 5.308; 95% CI, 1.824-15.447) and computed tomography (CT) obstruction index (P = 0.034; HR, 1.090; 95% CI, 1.006-1.181). In conclusion, provoked-iRF has a poorer prognosis than unprovoked PE and provoked-rRF. Renal insufficiency, high CRP, and CT obstruction index are poor prognostic factors in unprovoked PE. The Korean Academy of Medical Sciences 2012-11 2012-10-30 /pmc/articles/PMC3492669/ /pubmed/23166416 http://dx.doi.org/10.3346/jkms.2012.27.11.1347 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Uhm, Jae-Sun Jung, Hae-Ok Kim, Chan-Joon Kim, Tae-Hoon Youn, Ho-Joong Baek, Sang Hong Chung, Wook-Sung Seung, Ki Bae Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans |
title | Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans |
title_full | Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans |
title_fullStr | Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans |
title_full_unstemmed | Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans |
title_short | Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans |
title_sort | comparison of clinical and imaging characteristics and outcomes between provoked and unprovoked acute pulmonary embolism in koreans |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492669/ https://www.ncbi.nlm.nih.gov/pubmed/23166416 http://dx.doi.org/10.3346/jkms.2012.27.11.1347 |
work_keys_str_mv | AT uhmjaesun comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT junghaeok comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT kimchanjoon comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT kimtaehoon comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT younhojoong comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT baeksanghong comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT chungwooksung comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans AT seungkibae comparisonofclinicalandimagingcharacteristicsandoutcomesbetweenprovokedandunprovokedacutepulmonaryembolisminkoreans |