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Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans

This study was performed to compare clinical and imaging parameters and prognosis of unprovoked pulmonary embolism (PE), provoked PE with reversible risk factors (provoked-rRF), and provoked PE with irreversible risk factors (provoked-iRF) in Koreans. Three hundred consecutive patients (mean age, 63...

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Autores principales: Uhm, Jae-Sun, Jung, Hae-Ok, Kim, Chan-Joon, Kim, Tae-Hoon, Youn, Ho-Joong, Baek, Sang Hong, Chung, Wook-Sung, Seung, Ki Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492669/
https://www.ncbi.nlm.nih.gov/pubmed/23166416
http://dx.doi.org/10.3346/jkms.2012.27.11.1347
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author Uhm, Jae-Sun
Jung, Hae-Ok
Kim, Chan-Joon
Kim, Tae-Hoon
Youn, Ho-Joong
Baek, Sang Hong
Chung, Wook-Sung
Seung, Ki Bae
author_facet Uhm, Jae-Sun
Jung, Hae-Ok
Kim, Chan-Joon
Kim, Tae-Hoon
Youn, Ho-Joong
Baek, Sang Hong
Chung, Wook-Sung
Seung, Ki Bae
author_sort Uhm, Jae-Sun
collection PubMed
description This study was performed to compare clinical and imaging parameters and prognosis of unprovoked pulmonary embolism (PE), provoked PE with reversible risk factors (provoked-rRF), and provoked PE with irreversible risk factors (provoked-iRF) in Koreans. Three hundred consecutive patients (mean age, 63.6 ± 15.0 yr; 42.8% male) diagnosed with acute PE were included. The patients were classified into 3 groups; unprovoked PE, provoked-rRF, and provoked-iRF; 43.7%, 14.7%, and 41.7%, respectively. We followed up the patients for 25.4 ± 33.7 months. Composite endpoint was all-cause mortality and recurrent PE. The provoked-iRF group had significantly higher all-cause mortality, mortality from PE and recurrent PE than the unprovoked and provoked-rRF groups (P < 0.001, P < 0.001, and P = 0.034, respectively). Prognostic factors of composite endpoint in the unprovoked group were high creatinine (> 1.2 mg/dL; P < 0.001; hazard ratio [HR], 4.735; 95% confidence interval [CI], 1.845-12.152), C-reactive protein (CRP; > 5 mg/L; P = 0.002; HR, 5.308; 95% CI, 1.824-15.447) and computed tomography (CT) obstruction index (P = 0.034; HR, 1.090; 95% CI, 1.006-1.181). In conclusion, provoked-iRF has a poorer prognosis than unprovoked PE and provoked-rRF. Renal insufficiency, high CRP, and CT obstruction index are poor prognostic factors in unprovoked PE.
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spelling pubmed-34926692012-11-19 Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans Uhm, Jae-Sun Jung, Hae-Ok Kim, Chan-Joon Kim, Tae-Hoon Youn, Ho-Joong Baek, Sang Hong Chung, Wook-Sung Seung, Ki Bae J Korean Med Sci Original Article This study was performed to compare clinical and imaging parameters and prognosis of unprovoked pulmonary embolism (PE), provoked PE with reversible risk factors (provoked-rRF), and provoked PE with irreversible risk factors (provoked-iRF) in Koreans. Three hundred consecutive patients (mean age, 63.6 ± 15.0 yr; 42.8% male) diagnosed with acute PE were included. The patients were classified into 3 groups; unprovoked PE, provoked-rRF, and provoked-iRF; 43.7%, 14.7%, and 41.7%, respectively. We followed up the patients for 25.4 ± 33.7 months. Composite endpoint was all-cause mortality and recurrent PE. The provoked-iRF group had significantly higher all-cause mortality, mortality from PE and recurrent PE than the unprovoked and provoked-rRF groups (P < 0.001, P < 0.001, and P = 0.034, respectively). Prognostic factors of composite endpoint in the unprovoked group were high creatinine (> 1.2 mg/dL; P < 0.001; hazard ratio [HR], 4.735; 95% confidence interval [CI], 1.845-12.152), C-reactive protein (CRP; > 5 mg/L; P = 0.002; HR, 5.308; 95% CI, 1.824-15.447) and computed tomography (CT) obstruction index (P = 0.034; HR, 1.090; 95% CI, 1.006-1.181). In conclusion, provoked-iRF has a poorer prognosis than unprovoked PE and provoked-rRF. Renal insufficiency, high CRP, and CT obstruction index are poor prognostic factors in unprovoked PE. The Korean Academy of Medical Sciences 2012-11 2012-10-30 /pmc/articles/PMC3492669/ /pubmed/23166416 http://dx.doi.org/10.3346/jkms.2012.27.11.1347 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Uhm, Jae-Sun
Jung, Hae-Ok
Kim, Chan-Joon
Kim, Tae-Hoon
Youn, Ho-Joong
Baek, Sang Hong
Chung, Wook-Sung
Seung, Ki Bae
Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
title Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
title_full Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
title_fullStr Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
title_full_unstemmed Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
title_short Comparison of Clinical and Imaging Characteristics and Outcomes between Provoked and Unprovoked Acute Pulmonary Embolism in Koreans
title_sort comparison of clinical and imaging characteristics and outcomes between provoked and unprovoked acute pulmonary embolism in koreans
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492669/
https://www.ncbi.nlm.nih.gov/pubmed/23166416
http://dx.doi.org/10.3346/jkms.2012.27.11.1347
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