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Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience

Primary CNS lymphoma (PCNSL) is a very uncommon disease in children, and usually treated by chemotherapy, combined with focal or craniospinal radiotherapy (RT). However, adverse effects of RT are a concern. We evaluated the outcomes of childhood PCNSL, treated with systemic and intrathecal chemother...

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Autores principales: Yoon, Jong Hyung, Kang, Hyoung Jin, Kim, Hyery, Lee, Ji Won, Park, June Dong, Park, Kyung Duk, Shin, Hee Young, Ahn, Hyo Seop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492674/
https://www.ncbi.nlm.nih.gov/pubmed/23166421
http://dx.doi.org/10.3346/jkms.2012.27.11.1378
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author Yoon, Jong Hyung
Kang, Hyoung Jin
Kim, Hyery
Lee, Ji Won
Park, June Dong
Park, Kyung Duk
Shin, Hee Young
Ahn, Hyo Seop
author_facet Yoon, Jong Hyung
Kang, Hyoung Jin
Kim, Hyery
Lee, Ji Won
Park, June Dong
Park, Kyung Duk
Shin, Hee Young
Ahn, Hyo Seop
author_sort Yoon, Jong Hyung
collection PubMed
description Primary CNS lymphoma (PCNSL) is a very uncommon disease in children, and usually treated by chemotherapy, combined with focal or craniospinal radiotherapy (RT). However, adverse effects of RT are a concern. We evaluated the outcomes of childhood PCNSL, treated with systemic and intrathecal chemotherapy, but without RT. For fifteen years, six patients among 175 of non-Hodgkin lymphoma were diagnosed as PCNSL in Seoul National University Children's Hospital and we analyzed their medical records retrospectively. Their male:female ratio was 5:1, and median age was 10.1 yr. The primary sites were the sellar area in three patients, parietal area in one, cerebellum in one, and multiple areas in one. Their pathologic diagnoses were diffuse large B-cell lymphoma in three patients, Burkitt lymphoma in two, and undifferentiated B-cell lymphoma in one. Five were treated with the LMB96 treatment protocol, and one was treated with the CCG-106B protocol. None had RT as a first-line treatment. One patient had a local relapse and received RT and salvage chemotherapy, without success. No patient had treatment-related mortality. Their estimated 5-yr event-free and overall survival rates were both 83.3%. In conclusion, PCNSL is a rare disease in childhood, but successfully treated by chemotherapy without RT.
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spelling pubmed-34926742012-11-19 Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience Yoon, Jong Hyung Kang, Hyoung Jin Kim, Hyery Lee, Ji Won Park, June Dong Park, Kyung Duk Shin, Hee Young Ahn, Hyo Seop J Korean Med Sci Original Article Primary CNS lymphoma (PCNSL) is a very uncommon disease in children, and usually treated by chemotherapy, combined with focal or craniospinal radiotherapy (RT). However, adverse effects of RT are a concern. We evaluated the outcomes of childhood PCNSL, treated with systemic and intrathecal chemotherapy, but without RT. For fifteen years, six patients among 175 of non-Hodgkin lymphoma were diagnosed as PCNSL in Seoul National University Children's Hospital and we analyzed their medical records retrospectively. Their male:female ratio was 5:1, and median age was 10.1 yr. The primary sites were the sellar area in three patients, parietal area in one, cerebellum in one, and multiple areas in one. Their pathologic diagnoses were diffuse large B-cell lymphoma in three patients, Burkitt lymphoma in two, and undifferentiated B-cell lymphoma in one. Five were treated with the LMB96 treatment protocol, and one was treated with the CCG-106B protocol. None had RT as a first-line treatment. One patient had a local relapse and received RT and salvage chemotherapy, without success. No patient had treatment-related mortality. Their estimated 5-yr event-free and overall survival rates were both 83.3%. In conclusion, PCNSL is a rare disease in childhood, but successfully treated by chemotherapy without RT. The Korean Academy of Medical Sciences 2012-11 2012-10-30 /pmc/articles/PMC3492674/ /pubmed/23166421 http://dx.doi.org/10.3346/jkms.2012.27.11.1378 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Jong Hyung
Kang, Hyoung Jin
Kim, Hyery
Lee, Ji Won
Park, June Dong
Park, Kyung Duk
Shin, Hee Young
Ahn, Hyo Seop
Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience
title Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience
title_full Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience
title_fullStr Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience
title_full_unstemmed Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience
title_short Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center Experience
title_sort successful treatment of primary central nervous system lymphoma without irradiation in children: single center experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492674/
https://www.ncbi.nlm.nih.gov/pubmed/23166421
http://dx.doi.org/10.3346/jkms.2012.27.11.1378
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