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Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy

Few studies have included magnetoencephalography (MEG) when assessing the diagnostic value of presurgical modalities in a nonlesional epilepsy population. Here, we compare single photon emission computed tomography (SPECT), positron emission tomography (PET), video-EEG (VEEG), and MEG, with intracra...

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Autores principales: Jeong, Woorim, Chung, Chun Kee, Kim, June Sic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492676/
https://www.ncbi.nlm.nih.gov/pubmed/23166423
http://dx.doi.org/10.3346/jkms.2012.27.11.1391
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author Jeong, Woorim
Chung, Chun Kee
Kim, June Sic
author_facet Jeong, Woorim
Chung, Chun Kee
Kim, June Sic
author_sort Jeong, Woorim
collection PubMed
description Few studies have included magnetoencephalography (MEG) when assessing the diagnostic value of presurgical modalities in a nonlesional epilepsy population. Here, we compare single photon emission computed tomography (SPECT), positron emission tomography (PET), video-EEG (VEEG), and MEG, with intracranial EEG (iEEG) to determine the value of individual modalities to surgical decisions. We analyzed 23 adult epilepsy patients with no abnormal MRI findings who had undergone surgical resection. Localization of individual presurgical tests was determined for hemispheric and lobar locations based on visual analysis. Each localization result was compared with the ictal onset zone (IOZ) defined by using iEEG. The highest to the lowest hemispheric concordance rates were MEG (83%) > ictal VEEG (78%) > PET (70%) > ictal SPECT (57%). The highest to lowest lobar concordance rates were ictal VEEG = MEG (65%) > PET (57%) > ictal SPECT (52%). Statistical analysis showed MEG to have a higher hemispheric concordance than that of ictal SPECT (P = 0.031). We analyzed the effects of MEG clustered-area resection on surgical outcome. Patients who had resection of MEG clusters showed a better surgical outcome than those without such resection (P = 0.038). It is suggested that MEG-based localization had the highest concordance with the iEEG-defined IOZ. Furthermore, MEG cluster resection has prognostic significance in predicting surgical outcome.
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spelling pubmed-34926762012-11-19 Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy Jeong, Woorim Chung, Chun Kee Kim, June Sic J Korean Med Sci Original Article Few studies have included magnetoencephalography (MEG) when assessing the diagnostic value of presurgical modalities in a nonlesional epilepsy population. Here, we compare single photon emission computed tomography (SPECT), positron emission tomography (PET), video-EEG (VEEG), and MEG, with intracranial EEG (iEEG) to determine the value of individual modalities to surgical decisions. We analyzed 23 adult epilepsy patients with no abnormal MRI findings who had undergone surgical resection. Localization of individual presurgical tests was determined for hemispheric and lobar locations based on visual analysis. Each localization result was compared with the ictal onset zone (IOZ) defined by using iEEG. The highest to the lowest hemispheric concordance rates were MEG (83%) > ictal VEEG (78%) > PET (70%) > ictal SPECT (57%). The highest to lowest lobar concordance rates were ictal VEEG = MEG (65%) > PET (57%) > ictal SPECT (52%). Statistical analysis showed MEG to have a higher hemispheric concordance than that of ictal SPECT (P = 0.031). We analyzed the effects of MEG clustered-area resection on surgical outcome. Patients who had resection of MEG clusters showed a better surgical outcome than those without such resection (P = 0.038). It is suggested that MEG-based localization had the highest concordance with the iEEG-defined IOZ. Furthermore, MEG cluster resection has prognostic significance in predicting surgical outcome. The Korean Academy of Medical Sciences 2012-11 2012-10-30 /pmc/articles/PMC3492676/ /pubmed/23166423 http://dx.doi.org/10.3346/jkms.2012.27.11.1391 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jeong, Woorim
Chung, Chun Kee
Kim, June Sic
Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy
title Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy
title_full Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy
title_fullStr Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy
title_full_unstemmed Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy
title_short Localization Value of Magnetoencephalography Interictal Spikes in Adult Nonlesional Neocortical Epilepsy
title_sort localization value of magnetoencephalography interictal spikes in adult nonlesional neocortical epilepsy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492676/
https://www.ncbi.nlm.nih.gov/pubmed/23166423
http://dx.doi.org/10.3346/jkms.2012.27.11.1391
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