Cargando…

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalytic components of γ-secretase, and γ-secretase activity itself, are highly enriched in a subcompartmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Area-Gomez, Estela, del Carmen Lara Castillo, Maria, Tambini, Marc D, Guardia-Laguarta, Cristina, de Groof, Ad J C, Madra, Moneek, Ikenouchi, Junichi, Umeda, Masato, Bird, Thomas D, Sturley, Stephen L, Schon, Eric A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492725/ https://www.ncbi.nlm.nih.gov/pubmed/22892566 http://dx.doi.org/10.1038/emboj.2012.202

Ejemplares similares

ApoE4 upregulates the activity of mitochondria‐associated ER membranes
por: Tambini, Marc D, et al.
Publicado: (2015)

Novel subcellular localization for α-synuclein: possible functional consequences
por: Guardia-Laguarta, Cristina, et al.
Publicado: (2015)

MFN2 mutations in Charcot–Marie–Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics
por: Larrea, Delfina, et al.
Publicado: (2019)

Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
por: Pera, Marta, et al.
Publicado: (2017)

Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury
por: Agrawal, Rishi R., et al.
Publicado: (2022)

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease
por: Area-Gomez, Estela, et al.
Publicado: (2018)

Ethanol Induces Extracellular Vesicle Secretion by Altering Lipid Metabolism through the Mitochondria-Associated ER Membranes and Sphingomyelinases
por: Ibáñez, Francesc, et al.
Publicado: (2021)

Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance
por: Çoku, Jorida, et al.
Publicado: (2022)

Lipid level alteration in human and cellular models of alpha synuclein mutations
por: Avisar, Hila, et al.
Publicado: (2022)

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking
por: Montesinos, Jorge, et al.
Publicado: (2020)

Redox signals at the ER–mitochondria interface control melanoma progression
por: Zhang, Xin, et al.
Publicado: (2019)

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts
por: Murley, Andrew, et al.
Publicado: (2015)

ER–mitochondria signaling in Parkinson’s disease
por: Gómez-Suaga, Patricia, et al.
Publicado: (2018)

ER-mitochondria signaling regulates autophagy
por: Gomez-Suaga, Patricia, et al.
Publicado: (2017)

Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization
por: Ikenouchi, Junichi, et al.
Publicado: (2007)

STAT3 Localizes in Mitochondria-Associated ER Membranes Instead of in Mitochondria
por: Su, Yixun, et al.
Publicado: (2020)

FAM134B-mediated ER-phagy regulates ER-mitochondria interaction through MAMs: FAM134B-mediated ER-phagy regulates ER-mitochondria interaction
por: Chen, Wei, et al.
Publicado: (2021)

Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases
por: Annunziata, Ida, et al.
Publicado: (2018)

Mitochondria sensitive to ER Ca(2+) stores
por: LeBrasseur, Nicole
Publicado: (2003)

The “sweet” side of ER-mitochondria contact sites
por: Demetriadou, Anthi, et al.
Publicado: (2017)

In situ architecture of the ER-mitochondria encounter structure
por: Wozny, Michael R., et al.
Publicado: (2023)

Role of Mitochondria–ER Contact Sites in Mitophagy
por: Rühmkorf, Alina, et al.
Publicado: (2023)

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism
por: Ma, Xiaowen, et al.
Publicado: (2021)

The Interface Between ER and Mitochondria: Molecular Compositions and Functions
por: Lee, Soyeon, et al.
Publicado: (2018)

Pannexin 2 Localizes at ER-Mitochondria Contact Sites
por: Le Vasseur, Maxence, et al.
Publicado: (2019)

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy
por: Yang, Ming, et al.
Publicado: (2020)

ER-Mitochondria Communication in Cells of the Innate Immune System
por: Namgaladze, Dmitry, et al.
Publicado: (2019)

ER-SURF: Riding the Endoplasmic Reticulum Surface to Mitochondria
por: Koch, Christian, et al.
Publicado: (2021)

Cellular senescence links mitochondria-ER contacts and aging
por: Ziegler, Dorian V., et al.
Publicado: (2021)

Serine palmitoyltransferase assembles at ER–mitochondria contact sites
por: Aaltonen, Mari J, et al.
Publicado: (2021)

Mitochondria- and ER-associated actin are required for mitochondrial fusion
por: Gatti, Priya, et al.
Publicado: (2023)

ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer
por: Ouyang, Yi-Bing, et al.
Publicado: (2012)

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis
por: Tadic, Vedrana, et al.
Publicado: (2014)

ER–mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release
por: Steffen, Janos, et al.
Publicado: (2018)

The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity
por: Paradis, Marie, et al.
Publicado: (2022)

ER–mitochondria contacts promote mitochondrial-derived compartment biogenesis
por: English, Alyssa M., et al.
Publicado: (2020)

Natural Products Targeting ER Stress, and the Functional Link to Mitochondria
por: Martucciello, Stefania, et al.
Publicado: (2020)

Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease?
por: Li, Jin, et al.
Publicado: (2019)

β2-adrenergic receptor regulates ER-mitochondria contacts
por: Lim, Youngshin, et al.
Publicado: (2021)

Cnm1: A bridge between mitochondria and nuclear ER
por: Casler, Jason C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_oavcs0trlmuc5a8to5dq1bfltt