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Variation in germ line mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

A genetic bottleneck explains the marked changes in mitochondrial DNA (mtDNA) heteroplasmy observed during the transmission of pathogenic mutations, but the precise timing remains controversial, and it is not clear whether selection plays a role. These issues are critically important for the genetic...

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Detalles Bibliográficos
Autores principales:	Freyer, Christoph, Cree, Lynsey M., Mourier, Arnaud, Stewart, James B., Koolmeister, Camilla, Milenkovic, Dusanka, Wai, Timothy, Floros, Vasileios I., Hagström, Erik, Chatzidaki, Emmanouella E., Wiesner, Rudolph J., Samuels, David C, Larsson, Nils-Göran, Chinnery, Patrick F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492742/ https://www.ncbi.nlm.nih.gov/pubmed/23042113 http://dx.doi.org/10.1038/ng.2427

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