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Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease

Collective and directed cell movements are crucial for diverse developmental processes in the animal kingdom, but they are also involved in wound repair and disease. During these processes groups of cells are oriented within the tissue plane, which is referred to as planar cell polarity (PCP). This...

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Autores principales: Muñoz-Soriano, Verónica, Belacortu, Yaiza, Paricio, Nuria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492801/
https://www.ncbi.nlm.nih.gov/pubmed/23730201
http://dx.doi.org/10.2174/138920212803759721
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author Muñoz-Soriano, Verónica
Belacortu, Yaiza
Paricio, Nuria
author_facet Muñoz-Soriano, Verónica
Belacortu, Yaiza
Paricio, Nuria
author_sort Muñoz-Soriano, Verónica
collection PubMed
description Collective and directed cell movements are crucial for diverse developmental processes in the animal kingdom, but they are also involved in wound repair and disease. During these processes groups of cells are oriented within the tissue plane, which is referred to as planar cell polarity (PCP). This requires a tight regulation that is in part conducted by the PCP pathway. Although this pathway was initially characterized in flies, subsequent studies in vertebrates revealed a set of conserved core factors but also effector molecules and signal modulators, which build the fundamental PCP machinery. The PCP pathway in Drosophila regulates several developmental processes involving collective cell movements such as border cell migration during oogenesis, ommatidial rotation during eye development, and embryonic dorsal closure. During vertebrate embryogenesis, PCP signaling also controls collective and directed cell movements including convergent extension during gastrulation, neural tube closure, neural crest cell migration, or heart morphogenesis. Similarly, PCP signaling is linked to processes such as wound repair, and cancer invasion and metastasis in adults. As a consequence, disruption of PCP signaling leads to pathological conditions. In this review, we will summarize recent findings about the role of PCP signaling in collective cell movements in flies and vertebrates. In addition, we will focus on how studies in Drosophila have been relevant to our understanding of the PCP molecular machinery and will describe several developmental defects and human disorders in which PCP signaling is compromised. Therefore, new discoveries about the contribution of this pathway to collective cell movements could provide new potential diagnostic and therapeutic targets for these disorders.
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spelling pubmed-34928012013-06-01 Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease Muñoz-Soriano, Verónica Belacortu, Yaiza Paricio, Nuria Curr Genomics Article Collective and directed cell movements are crucial for diverse developmental processes in the animal kingdom, but they are also involved in wound repair and disease. During these processes groups of cells are oriented within the tissue plane, which is referred to as planar cell polarity (PCP). This requires a tight regulation that is in part conducted by the PCP pathway. Although this pathway was initially characterized in flies, subsequent studies in vertebrates revealed a set of conserved core factors but also effector molecules and signal modulators, which build the fundamental PCP machinery. The PCP pathway in Drosophila regulates several developmental processes involving collective cell movements such as border cell migration during oogenesis, ommatidial rotation during eye development, and embryonic dorsal closure. During vertebrate embryogenesis, PCP signaling also controls collective and directed cell movements including convergent extension during gastrulation, neural tube closure, neural crest cell migration, or heart morphogenesis. Similarly, PCP signaling is linked to processes such as wound repair, and cancer invasion and metastasis in adults. As a consequence, disruption of PCP signaling leads to pathological conditions. In this review, we will summarize recent findings about the role of PCP signaling in collective cell movements in flies and vertebrates. In addition, we will focus on how studies in Drosophila have been relevant to our understanding of the PCP molecular machinery and will describe several developmental defects and human disorders in which PCP signaling is compromised. Therefore, new discoveries about the contribution of this pathway to collective cell movements could provide new potential diagnostic and therapeutic targets for these disorders. Bentham Science Publishers 2012-12 2012-12 /pmc/articles/PMC3492801/ /pubmed/23730201 http://dx.doi.org/10.2174/138920212803759721 Text en ©2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Muñoz-Soriano, Verónica
Belacortu, Yaiza
Paricio, Nuria
Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
title Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
title_full Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
title_fullStr Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
title_full_unstemmed Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
title_short Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
title_sort planar cell polarity signaling in collective cell movements during morphogenesis and disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492801/
https://www.ncbi.nlm.nih.gov/pubmed/23730201
http://dx.doi.org/10.2174/138920212803759721
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