Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms

Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machine...

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Detalles Bibliográficos
Autores principales: Lin, Yi-Tzu, Verma, Amanda, Hodgkinson, Conrad P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492803/
https://www.ncbi.nlm.nih.gov/pubmed/23730203
http://dx.doi.org/10.2174/138920212803759712
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author Lin, Yi-Tzu
Verma, Amanda
Hodgkinson, Conrad P
author_facet Lin, Yi-Tzu
Verma, Amanda
Hodgkinson, Conrad P
author_sort Lin, Yi-Tzu
collection PubMed
description Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.
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spelling pubmed-34928032013-06-01 Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms Lin, Yi-Tzu Verma, Amanda Hodgkinson, Conrad P Curr Genomics Article Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease. Bentham Science Publishers 2012-12 2012-12 /pmc/articles/PMC3492803/ /pubmed/23730203 http://dx.doi.org/10.2174/138920212803759712 Text en ©2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Lin, Yi-Tzu
Verma, Amanda
Hodgkinson, Conrad P
Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
title Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
title_full Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
title_fullStr Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
title_full_unstemmed Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
title_short Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
title_sort toll-like receptors and human disease: lessons from single nucleotide polymorphisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492803/
https://www.ncbi.nlm.nih.gov/pubmed/23730203
http://dx.doi.org/10.2174/138920212803759712
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