Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy

To investigate whether altered energy metabolism induces the Warburg effect and results in tumor malignancy, the respiratory enzyme citrate synthase (CS) was examined, silenced, and the effects analyzed. In human cervical carcinoma cells, RNAi-mediated CS knockdown induced morphological changes char...

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Detalles Bibliográficos
Autores principales: Lin, Chin-Chih, Cheng, Tsung-Lin, Tsai, Wen-Hui, Tsai, Hui-Ju, Hu, Keng-Hsun, Chang, Hao-Chun, Yeh, Chin-Wei, Chen, Ying-Chou, Liao, Ching-Chun, Chang, Wen-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492867/
https://www.ncbi.nlm.nih.gov/pubmed/23139858
http://dx.doi.org/10.1038/srep00785

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