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Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family

To investigate the range of autoinhibitory mechanisms used by TKDs (tyrosine kinase domains) from the insulin receptor family of RTKs (receptor tyrosine kinases), we determined crystal structures of TKDs from TrkA (tropomyosin receptor kinase A, a nerve growth factor receptor) and Ror2 (receptor tyr...

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Detalles Bibliográficos
Autores principales:	Artim, Stephen C., Mendrola, Jeannine M., Lemmon, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492919/ https://www.ncbi.nlm.nih.gov/pubmed/22992069 http://dx.doi.org/10.1042/BJ20121365

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