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Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing

Concerns over cardiac side effects are the largest single cause of compound attrition during pharmaceutical drug development. For a number of years, biophysically detailed mathematical models of cardiac electrical activity have been used to explore how a compound, interfering with specific ion-chann...

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Detalles Bibliográficos
Autores principales:	Mirams, Gary R, Davies, Mark R, Cui, Yi, Kohl, Peter, Noble, Denis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Review with Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492977/ https://www.ncbi.nlm.nih.gov/pubmed/22568589 http://dx.doi.org/10.1111/j.1476-5381.2012.02020.x

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