Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?

BACKGROUND: Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce. METHODS: We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a coh...

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Detalles Bibliográficos
Autores principales: Olazarán, Javier, Navarro, Eloísa, Rojo, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493007/
https://www.ncbi.nlm.nih.gov/pubmed/23139685
http://dx.doi.org/10.1159/000342346
Descripción
Sumario:BACKGROUND: Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce. METHODS: We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usual practice. RESULTS: A total of 137 patients with probable AD and 66 patients with ADVC were studied during a mean follow-up period of 2.8 years. Univariate analyses demonstrated worse functional evolution and anticipation of psychotic symptoms and agitation in the ADVC group. CONCLUSIONS: The present results are consistent with an additive model of predominantly frontal-subcortical vascular damage in AD.

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