Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?

BACKGROUND: Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce. METHODS: We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a coh...

Descripción completa

Detalles Bibliográficos
Autores principales: Olazarán, Javier, Navarro, Eloísa, Rojo, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493007/
https://www.ncbi.nlm.nih.gov/pubmed/23139685
http://dx.doi.org/10.1159/000342346
_version_ 1782249199264333824
author Olazarán, Javier
Navarro, Eloísa
Rojo, José Manuel
author_facet Olazarán, Javier
Navarro, Eloísa
Rojo, José Manuel
author_sort Olazarán, Javier
collection PubMed
description BACKGROUND: Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce. METHODS: We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usual practice. RESULTS: A total of 137 patients with probable AD and 66 patients with ADVC were studied during a mean follow-up period of 2.8 years. Univariate analyses demonstrated worse functional evolution and anticipation of psychotic symptoms and agitation in the ADVC group. CONCLUSIONS: The present results are consistent with an additive model of predominantly frontal-subcortical vascular damage in AD.
format Online
Article
Text
id pubmed-3493007
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-34930072012-11-08 Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity? Olazarán, Javier Navarro, Eloísa Rojo, José Manuel Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND: Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce. METHODS: We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usual practice. RESULTS: A total of 137 patients with probable AD and 66 patients with ADVC were studied during a mean follow-up period of 2.8 years. Univariate analyses demonstrated worse functional evolution and anticipation of psychotic symptoms and agitation in the ADVC group. CONCLUSIONS: The present results are consistent with an additive model of predominantly frontal-subcortical vascular damage in AD. S. Karger AG 2012-09-22 /pmc/articles/PMC3493007/ /pubmed/23139685 http://dx.doi.org/10.1159/000342346 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Research Article
Olazarán, Javier
Navarro, Eloísa
Rojo, José Manuel
Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?
title Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?
title_full Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?
title_fullStr Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?
title_full_unstemmed Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?
title_short Alzheimer's Disease with Vascular Component: A Distinct Clinical Entity?
title_sort alzheimer's disease with vascular component: a distinct clinical entity?
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493007/
https://www.ncbi.nlm.nih.gov/pubmed/23139685
http://dx.doi.org/10.1159/000342346
work_keys_str_mv AT olazaranjavier alzheimersdiseasewithvascularcomponentadistinctclinicalentity
AT navarroeloisa alzheimersdiseasewithvascularcomponentadistinctclinicalentity
AT rojojosemanuel alzheimersdiseasewithvascularcomponentadistinctclinicalentity

Ejemplares similares