Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin

Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immun...

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Autores principales: Fujimura, Taku, Kakizaki, Aya, Kambayashi, Yumi, Furudate, Sadanori, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published online: October, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493012/
https://www.ncbi.nlm.nih.gov/pubmed/23139659
http://dx.doi.org/10.1159/000343882
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author Fujimura, Taku
Kakizaki, Aya
Kambayashi, Yumi
Furudate, Sadanori
Aiba, Setsuya
author_facet Fujimura, Taku
Kakizaki, Aya
Kambayashi, Yumi
Furudate, Sadanori
Aiba, Setsuya
author_sort Fujimura, Taku
collection PubMed
description Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.
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spelling pubmed-34930122012-11-08 Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin Fujimura, Taku Kakizaki, Aya Kambayashi, Yumi Furudate, Sadanori Aiba, Setsuya Case Rep Dermatol Published online: October, 2012 Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA. S. Karger AG 2012-10-12 /pmc/articles/PMC3493012/ /pubmed/23139659 http://dx.doi.org/10.1159/000343882 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: October, 2012
Fujimura, Taku
Kakizaki, Aya
Kambayashi, Yumi
Furudate, Sadanori
Aiba, Setsuya
Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
title Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
title_full Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
title_fullStr Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
title_full_unstemmed Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
title_short Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
title_sort bullous pemphigoid accompanied by aplastic anemia: the induction of il-17-producing cells in the affected areas of the skin
topic Published online: October, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493012/
https://www.ncbi.nlm.nih.gov/pubmed/23139659
http://dx.doi.org/10.1159/000343882
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