Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression

We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T...

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Detalles Bibliográficos
Autores principales: Furudate, Sadanori, Fujimura, Taku, Tsukada, Akira, Numata, Yukikazu, Kambayashi, Yumi, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published online: October, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493020/
https://www.ncbi.nlm.nih.gov/pubmed/23139660
http://dx.doi.org/10.1159/000343881
Descripción
Sumario:We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.

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