Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression

We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T...

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Autores principales: Furudate, Sadanori, Fujimura, Taku, Tsukada, Akira, Numata, Yukikazu, Kambayashi, Yumi, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published online: October, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493020/
https://www.ncbi.nlm.nih.gov/pubmed/23139660
http://dx.doi.org/10.1159/000343881
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author Furudate, Sadanori
Fujimura, Taku
Tsukada, Akira
Numata, Yukikazu
Kambayashi, Yumi
Aiba, Setsuya
author_facet Furudate, Sadanori
Fujimura, Taku
Tsukada, Akira
Numata, Yukikazu
Kambayashi, Yumi
Aiba, Setsuya
author_sort Furudate, Sadanori
collection PubMed
description We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.
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spelling pubmed-34930202012-11-08 Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression Furudate, Sadanori Fujimura, Taku Tsukada, Akira Numata, Yukikazu Kambayashi, Yumi Aiba, Setsuya Case Rep Dermatol Published online: October, 2012 We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment. S. Karger AG 2012-10-16 /pmc/articles/PMC3493020/ /pubmed/23139660 http://dx.doi.org/10.1159/000343881 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: October, 2012
Furudate, Sadanori
Fujimura, Taku
Tsukada, Akira
Numata, Yukikazu
Kambayashi, Yumi
Aiba, Setsuya
Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression
title Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression
title_full Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression
title_fullStr Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression
title_full_unstemmed Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression
title_short Profiles of Tumor-Infiltrating Lymphocytes in a Case of Trichilemmal Carcinoma with Spontaneous Regression
title_sort profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression
topic Published online: October, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493020/
https://www.ncbi.nlm.nih.gov/pubmed/23139660
http://dx.doi.org/10.1159/000343881
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