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Light-Activated Content Release from Liposomes
Successful integration of diagnostic and therapeutic actions at the level of individual cells requires new materials that combine biological compatibility with functional versatility. This review focuses on the development of liposome-based functional materials, where payload release is activated by...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493200/ https://www.ncbi.nlm.nih.gov/pubmed/23139729 http://dx.doi.org/10.7150/thno.4847 |
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author | Leung, Sarah J. Romanowski, Marek |
author_facet | Leung, Sarah J. Romanowski, Marek |
author_sort | Leung, Sarah J. |
collection | PubMed |
description | Successful integration of diagnostic and therapeutic actions at the level of individual cells requires new materials that combine biological compatibility with functional versatility. This review focuses on the development of liposome-based functional materials, where payload release is activated by light. Methods of sensitizing liposomes to light have progressed from the use of organic molecular moieties to the use of metallic plasmon resonant structures. This development has facilitated application of near infrared light for activation, which is preferred for its deep penetration and low phototoxicity in biological tissues. Presented mechanisms of light-activated liposomal content release enable precise in vitro manipulation of minute amounts of reagents, but their use in clinical diagnostic and therapeutic applications will require demonstration of safety and efficacy. |
format | Online Article Text |
id | pubmed-3493200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-34932002012-11-08 Light-Activated Content Release from Liposomes Leung, Sarah J. Romanowski, Marek Theranostics Review Successful integration of diagnostic and therapeutic actions at the level of individual cells requires new materials that combine biological compatibility with functional versatility. This review focuses on the development of liposome-based functional materials, where payload release is activated by light. Methods of sensitizing liposomes to light have progressed from the use of organic molecular moieties to the use of metallic plasmon resonant structures. This development has facilitated application of near infrared light for activation, which is preferred for its deep penetration and low phototoxicity in biological tissues. Presented mechanisms of light-activated liposomal content release enable precise in vitro manipulation of minute amounts of reagents, but their use in clinical diagnostic and therapeutic applications will require demonstration of safety and efficacy. Ivyspring International Publisher 2012-10-18 /pmc/articles/PMC3493200/ /pubmed/23139729 http://dx.doi.org/10.7150/thno.4847 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Review Leung, Sarah J. Romanowski, Marek Light-Activated Content Release from Liposomes |
title | Light-Activated Content Release from Liposomes |
title_full | Light-Activated Content Release from Liposomes |
title_fullStr | Light-Activated Content Release from Liposomes |
title_full_unstemmed | Light-Activated Content Release from Liposomes |
title_short | Light-Activated Content Release from Liposomes |
title_sort | light-activated content release from liposomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493200/ https://www.ncbi.nlm.nih.gov/pubmed/23139729 http://dx.doi.org/10.7150/thno.4847 |
work_keys_str_mv | AT leungsarahj lightactivatedcontentreleasefromliposomes AT romanowskimarek lightactivatedcontentreleasefromliposomes |